Epicatechin's cardiovascular protective effects are mediated via opioid receptors and nitric oxide

European Journal of Nutrition
Kirsty MacRaeAndrew S Fenning

Abstract

Cardiovascular disease is the leading cause of mortality globally. Epicatechin has previously been shown to improve vascular responses and possess cardioprotective properties. However, the mechanisms underpinning these cardiotropic outcomes remain unknown. The aim of this study was to further identify epicatechin's mechanism of action in the cardiovasculature. The effects of epicatechin on isolated rat conduit arteries, resistance vessels and cardiac electrophysiology were investigated on resting tension and precontracted vessels and cardiac action potential parameters, both in the presence and in the absence of various antagonists. At resting tension, epicatechin alone did not affect the vasoreactivity of either conduit or resistance vessels. In noradrenaline pre-contracted thoracic aortic arteries and potassium chloride pre-contracted mesenteric vessels, epicatechin (10-9-10-4 M) induced significant vasorelaxation. The addition of naloxone (10-5 M), NG-nitro-L-arginine methyl ester (10-5M), 4-aminopyridine (5 mM) and verapamil (10-5 M) attenuated epicatechin-mediated vasorelaxation. No change in epicatechin-mediated vasorelaxation was observed with the addition of atropine (10-5 M). Epicatechin significantly improved cardiac ...Continue Reading

References

Jun 3, 2000·Annual Review of Pharmacology and Toxicology·P Y LawH H Loh
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Sep 25, 2002·Life Sciences·Fujiko SanaeHisao Hayashi
Dec 5, 2003·Journal of Hypertension·Naomi D L FisherNorman K Hollenberg
Mar 17, 2004·Free Radical Biology & Medicine·Robert J WilliamsCatherine Rice-Evans
Apr 15, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Ezequiel Alvarez-CastroFrancisco Orallo
Jun 11, 2004·Journal of the American College of Nutrition·Mary B EnglerMichele L Mietus-Snyder
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Andrew FenningLindsay Brown
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hagen SchroeterMalte Kelm
Oct 27, 2007·Biochemical and Biophysical Research Communications·Kamilla KelemenChristoph A Karle
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Kiharu IgarashiYukihiko Hara
Feb 24, 2009·Critical Reviews in Food Science and Nutrition·Francesco VisioliRodolfo Paoletti
Jun 19, 2009·The Canadian Journal of Cardiology·Jean-Eric TarrideRon Goeree
Sep 16, 2009·The British Journal of Nutrition·Rosalind J MooreAnne M Minihane
Jul 17, 2010·Cardiovascular Therapeutics·Eberhard P ScholzChristoph A Karle
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Mathivadhani PanneerselvamHemal H Patel
Sep 15, 2010·Molecular Aspects of Medicine·Francisco Perez-Vizcaino, Juan Duarte
Sep 22, 2010·Molecular Aspects of Medicine·Cesar G FragaPatricia I Oteiza
Sep 30, 2010·Current Pharmaceutical Biotechnology·Vincent ChanLindsay Brown
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amynah A A PradhanBrigitte L Kieffer
Oct 25, 2011·Anesthesiology·Ream Al-Hasani, Michael R Bruchas
Nov 25, 2011·EMBO Molecular Medicine·Stefanie Dimmeler
Dec 30, 2011·Current Drug Targets·Yuan FengYing Xia
Mar 24, 2012·Journal of Agricultural and Food Chemistry·Rosario JiménezFrancisco Perez-Vizcaino
Jun 20, 2012·British Journal of Pharmacology·Amynah A PradhanChristopher J Evans
Jul 4, 2012·Current Pharmaceutical Design·John P HeadrickJason N Peart
Apr 30, 2013·Molecular Nutrition & Food Research·Mathivadhani PanneerselvamHemal H Patel
Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Marzena ChrostowskaKrzysztof Narkiewicz
Jul 13, 2013·Chinese Journal of Natural Medicines·Pooja Bhardwaj, Deepa Khanna
Apr 4, 2014·Advances in Pharmacological Sciences·Candice PullenAndrew Fenning
May 6, 2014·Bioorganic & Medicinal Chemistry Letters·Aldo Moreno-UlloaIsrael Ramirez-Sanchez

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Citations

Jun 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Douglas JacksonAndrew Fenning
Aug 17, 2020·European Journal of Pharmacology·Alejandra Garate-CarrilloIsrael Ramirez-Sanchez
Oct 12, 2020·Pharmacology & Therapeutics·Chunhui ZhaoLuqi Huang
Nov 24, 2021·Pflügers Archiv : European journal of physiology·Ezequiel J HidMonica Galleano

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