Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production

The Journal of Allergy and Clinical Immunology
Monika Majewska-SzczepanikMarian Szczepanik

Abstract

Subcutaneous allergen-specific immunotherapy is a standard route for the immunotherapy of allergic diseases. It modulates the course of allergy and can generate long-term remission. However, subcutaneous allergen-specific immunotherapy can also induce anaphylaxis in some patients, and therefore additional routes of administration should be investigated to improve the safety and tolerability of immunotherapy. We sought to determine whether epicutaneous treatment with antigen in the presence of a Toll-like receptor 9 agonist can suppress TH2-mediated responses in an antigen-specific manner. Epicutaneous immunization was performed by applying a skin patch soaked with ovalbumin (OVA) plus CpG, and its suppressor activity was determined by using the mouse model of atopic dermatitis. Finally, adoptive cell transfers were implemented to characterize the regulatory cells that are induced by epicutaneous immunization. Epicutaneous immunization with OVA and CpG reduces the production of OVA-specific IgE and increases the synthesis of OVA-specific IgG2a antibodies in an antigen-specific manner. Moreover, eosinophil peroxidase activity in the skin and production of IL-4, IL-5, IL-10, and IL-13 are suppressed. The observed reduction of IgE ...Continue Reading

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Citations

May 30, 2016·Pharmacological Reports : PR·Marian Szczepanik, Monika Majewska-Szczepanik
Apr 5, 2017·Current Opinion in Allergy and Clinical Immunology·Erika Jensen-JarolimFranziska Roth-Walter
Dec 17, 2017·Scientific Reports·Woon-Hae KimKwan-Kyu Park
May 22, 2019·Immunology·Erick Esteves de OliveiraAna Paula Ferreira
Nov 30, 2019·The Journal of Allergy and Clinical Immunology·Yang YuMei X Wu
Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus
Apr 13, 2021·Frontiers in Immunology·Yensheng WangMei X Wu
Jul 27, 2021·Frontiers in Immunology·Guirong LiuHuilian Che

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