Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice

The Journal of Clinical Investigation
J M SpergelR S Geha

Abstract

Our understanding of the pathogenesis of atopic dermatitis (AD) and its relationship to asthma remains incomplete. Herein, we describe a murine model of epicutaneous (EC) sensitization to the protein allergen, chicken egg albumin, ovalbumin (OVA), which results in a rise in total and OVA-specific serum IgE and leads to the development of a dermatitis characterized by infiltration of CD3(+) T cells, eosinophils, and neutrophils and by local expression of mRNA for the cytokines IL-4, IL-5, and interferon-gamma. A single exposure of the EC sensitized mice to aerosolized OVA induced eosinophilia in the bronchoalveolar lavage fluid and airway hyperresponsiveness to intravenous methacholine as assessed by measurement of pulmonary dynamic compliance (Cdyn). These results suggest a possible role for EC exposure to antigen in atopic dermatitis and in the development of allergic asthma.

References

Jan 1, 1992·Springer Seminars in Immunopathology·D Y Leung
Dec 1, 1992·Current Opinion in Immunology·D Vercelli, R S Geha
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Oct 1, 1989·Journal of the American Academy of Dermatology·R A Clark, A D Adinoff
Feb 1, 1988·The British Journal of Dermatology·C A Bruynzeel-KoomenP L Bruynzeel
Jan 16, 1982·Lancet·E B MitchellT A Platts-Mills
Jun 1, 1984·The British Journal of Dermatology·D L Roberts
Sep 1, 1995·The Journal of Allergy and Clinical Immunology·D Y Leung
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·K M Leiferman
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Aug 1, 1994·The Journal of Clinical Investigation·Q HamidD Y Leung
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·J SalogaE W Gelfand
Jan 1, 1996·The Journal of Experimental Medicine·J M DrazenK F Austen
May 1, 1996·The Journal of Allergy and Clinical Immunology·R A TupkerJ B van der Meer
Oct 1, 1996·The Journal of Experimental Medicine·J A MacLeanA D Luster
Oct 1, 1996·European Journal of Immunology·R W DenfeldJ C Simon
Oct 1, 1996·International Immunology·A M RangerL H Glimcher
Nov 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C H HsuK H Hsieh
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P D MehlhopH C Oettgen
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·E HamelmannE W Gelfand
Feb 3, 1997·The Journal of Experimental Medicine·R L Coffman, T von der Weid
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·J Hu-LiW E Paul
Mar 3, 1997·The Journal of Experimental Medicine·M KorsgrenC G Persson

❮ Previous
Next ❯

Citations

Mar 17, 2007·Cellular and Molecular Life Sciences : CMLS·S G Trivedi, C M Lloyd
Jun 22, 2005·Current Allergy and Asthma Reports·Tao Zheng, Zhou Zhu
Aug 11, 2006·Current Allergy and Asthma Reports·Peck Y Ong, Donald Y M Leung
Dec 29, 2007·Clinical Reviews in Allergy & Immunology·Y-S Dai
Mar 27, 2012·Immunologic Research·Lauren SteeleM Cecilia Berin
Nov 25, 2003·Current Opinion in Immunology·Raif S Geha
May 10, 2005·Immunology and Allergy Clinics of North America·Eugenia L Hahn, Leonard B Bacharier
Jan 15, 2009·Immunology and Allergy Clinics of North America·Soma JyonouchiJonathan M Spergel
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Dhafer LaouiniRaif S Geha
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Dhafer LaouiniRaif S Geha
Jun 21, 2002·Biochemical and Biophysical Research Communications·Chad K OhSeong H Cho
Jan 18, 2003·Lancet·Donald Y M Leung, Thomas Bieber
Jul 13, 2013·Lancet·Giorgio LongoEgidio Barbi
Sep 26, 2003·Journal of Dermatological Science·Hironori MatsushimaShinji Shimada
Aug 30, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nicola FuianoGianni Bona
Mar 31, 2010·Immunology and Cell Biology·Sandrine DubracSusanne Ebner
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rui HeRaif S Geha
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zhikun ZhangPierre Chambon
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michiko K OyoshiRaif S Geha
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Susanne StutteIrmgard Förster
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sumit PaliwalSamir Mitragotri
Mar 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michiko K OyoshiRaif S Geha
May 24, 2013·Archives of Environmental & Occupational Health·Sanghwan SongSeung-Do Yu
Aug 10, 2000·The Journal of Experimental Medicine·C M Williams, S J Galli
Oct 15, 2003·The Journal of Experimental Medicine·Frank BlaeserTalal A Chatila
Sep 26, 2003·Current Opinion in Pediatrics·Kelly D Stone
Jan 17, 2007·Current Opinion in Pediatrics·Brian P Vickery
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Pankaj Karande, Samir Mitragotri
Aug 3, 2004·The Journal of Clinical Investigation·Seiji KawamotoRaif S Geha
May 20, 2006·The Journal of Clinical Investigation·Mang YuStephen J Galli
May 4, 2006·The Journal of Clinical Investigation·Julia A Segre

❮ Previous
Next ❯

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