Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods

Applied and Environmental Microbiology
Suleyman YildirimSophia Kathariou

Abstract

Listeria monocytogenes contamination of ready-to-eat foods has been implicated in numerous outbreaks of food-borne listeriosis. However, the health hazards posed by L. monocytogenes detected in foods may vary, and speculations exist that strains actually implicated in illness may constitute only a fraction of those that contaminate foods. In this study, examination of 34 serogroup 4 (putative or confirmed serotype 4b) isolates of L. monocytogenes obtained from various foods and food-processing environments, without known implication in illness, revealed that many of these strains had methylation of cytosines at GATC sites in the genome, rendering their DNA resistant to digestion by the restriction endonuclease Sau3AI. These strains also harbored a gene cassette with putative restriction-modification system genes as well as other, genomically unlinked genetic markers characteristic of the major epidemic-associated lineage of L. monocytogenes (epidemic clone I), implicated in numerous outbreaks in Europe and North America. This may reflect a relatively high fitness of strains with these genetic markers in foods and food-related environments relative to other serotype 4b strains and may partially account for the repeated involveme...Continue Reading

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Citations

Nov 5, 2013·International Journal of Food Microbiology·G AlmeidaP Teixeira
Oct 14, 2008·Foodborne Pathogens and Disease·Vishal Singh PariharWilhelm Tham
Nov 17, 2009·Foodborne Pathogens and Disease·Henk C den BakkerMartin Wiedmann
Jul 31, 2012·Applied and Environmental Microbiology·Shakir S RataniSophia Kathariou
Dec 5, 2006·Applied and Environmental Microbiology·Cecilia A Rebuffo-ScheerSiegfried Scherer
Mar 23, 2010·Applied and Environmental Microbiology·Ying ChengS Kathariou
Dec 6, 2011·Applied and Environmental Microbiology·Sangmi LeeSophia Kathariou
Feb 8, 2008·Journal of Clinical Microbiology·Katharine E Volpe SperryLeslie A Wolf
Sep 17, 2013·Diagnostic Pathology·Hassan Momtaz, Shole Yadollahi
Jan 13, 2006·Avian Diseases·G R HuffR Nannapaneni
Feb 1, 2008·International Journal of Food Microbiology·Jon I EstebanAna Hurtado
Aug 28, 2007·Microbes and Infection·Carmen Buchrieser
Jan 18, 2015·Journal of Microbiological Methods·Joelle K SalazarWei Zhang
Sep 6, 2013·Journal of Clinical Microbiology·Thomas CantinelliSylvain Brisse
Jul 12, 2011·Journal of Food Protection·Dongryeoul BaeChinling Wang
Mar 29, 2007·Journal of Food Protection·Giovanna FranciosaPaolo Aureli

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