PMID: 11931204Apr 5, 2002Paper

Epidemic dropsy: observations on pathophysiology and clinical features during the Delhi epidemic of 1998

Tropical Doctor
B D SharmaA Mukharjee

Abstract

Epidemic dropsy results from the consumption of edible oils adulterated with Argemone mexicana oil by unscrupulous traders. Twenty consecutive 'in-door' patients of dropsy were intensively studied during the recent Delhi epidemic. Samples of edible oil used by them, their urine and their serum samples tested positive for sanguinarine on thin layer chromatography. The illness starts as a gastro-enteric illness followed by oliguria and pedal oedema. The following are often observed: cutaneous erythema with blanching and tenderness on pressure; violacious pigmentation of the skin; shortness of breath with orthopnoea; right-sided heart failure with normal left ventricle (LV) functions; as well as severe anaemia and hypoalbuminaemia. Renal function tests showed: bland urinary sediments; decreased glomerular filtration rate (GFR); mild to moderate azotaemia; acute tubular necrosis; patchy pneumonitis; moderate hypoxia with respiratory alkalosis; and restrictive ventilatory defects on blood gas analysis; and spirometry suggestive of interstitial pulmonary oedema of non-cardiogenic origin. 99mTc colloid sulphur liver scans showed colloid shift. There was marked dilatation and proliferation of dermal capillaries in the absence of signif...Continue Reading

References

Aug 1, 1975·The American Journal of Clinical Nutrition·R K TandonB N Tandon
Sep 1, 1988·Archives of Ophthalmology·M S SachdevN F Jaffery
Dec 1, 1963·Journal of Pharmaceutical Sciences·B C BOSES K SHARMA

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Citations

Aug 2, 2011·Journal of the American Veterinary Medical Association·Michael O ChildressHylton R Gelb
Jul 23, 2004·Tropical Doctor·K P S MalikMunish Dhawan

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