PMID: 108997Jun 1, 1979

Epidemic occurrence of neonatal necrotizing enterocolitis

American Journal of Diseases of Children
M GuinanW W Fox


In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC.


Sep 17, 1983·British Medical Journal
May 1, 1984·Archives of Disease in Childhood·V Y YuJ Astbury
Dec 14, 2011·American Journal of Epidemiology·Roger W RochatPolly A Marchbanks
Dec 5, 2003·Seminars in Pediatric Surgery·Russell T Blakelock, Spencer W Beasley
Jul 29, 2010·Pediatric Surgery International·Charles L SnyderShawn D St Peter
Dec 30, 2008·The Journal of Pediatrics·Jareen Meinzen-DerrPaul A Succop
Aug 1, 1980·Journal of Pediatric Surgery·A M Kosloske, J A Ulrich
Aug 20, 1997·British Journal of Hospital Medicine·A Pierro
Apr 1, 1987·Current Problems in Pediatrics·R M Kliegman, M C Walsh
Oct 1, 1984·The Journal of Surgical Research·S L Topalian, M M Ziegler
Apr 1, 1985·Journal of Pediatric Surgery·A M KosloskeB Skipper
Oct 1, 1982·Journal of Pediatric Surgery·M B MarchildonG Abdenour
Dec 20, 2007·Pediatric Research·Catherine J HunterVictoria Camerini
Apr 26, 1984·The New England Journal of Medicine·R M Kliegman, A A Fanaroff

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