PMID: 8615358May 1, 1996Paper

Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan

The American Journal of Clinical Nutrition
R ShodaN Umeda

Abstract

We examined the correlation between the incidence of Crohn disease and dietary change in a relatively homogeneous Japanese population. The incidence and daily intake of each dietary component were compared annually from 1966 to 1985. The univariate analysis showed that the increased incidence of Crohn disease was strongly (P < 0.001) correlated with increased dietary intake of total fat (r = 0.919). animal fat (r = 0.880), n-6 polyunsaturated fatty acids (r = 0.883), animal protein (r = 0.908), milk protein (r = 0.924), and the ratio of n-6 to n-3 fatty acid intake (r = 0.792). It was less correlated with intake of total protein (r = 0.482, P < 0.05), was not correlated with intake of fish protein (r = 0.055, P > 0.1), and was inversely correlated with intake of vegetable protein (r = -0.941, P < 0.001). The multivariate analysis showed that increased intake of animal protein was the strongest independent factor with a weaker second factor, an increased ration of n-6 to n-3 polyunsaturated fatty acids. The present study in association with reported clinical studies suggests that increased dietary intake of animal protein and n-6 polyunsaturated fatty acids with less n-3 polyunsaturated fatty acids may contribute to the developm...Continue Reading

Citations

Mar 30, 1999·The Proceedings of the Nutrition Society·R F Grimble
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P C Calder, R J Deckelbaum
Feb 1, 2003·European Journal of Gastroenterology & Hepatology·David A Gorard
Sep 26, 2002·The Proceedings of the Nutrition Society·Andrea Belluzzi
Jan 29, 2005·Inflammatory Bowel Diseases·Naomasa SakamotoUNKNOWN Epidemiology Group of the Research Committee on Inflammatory Bowel Disease in Japan
Sep 16, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Angie Macdonald
Nov 22, 2007·The American Journal of Gastroenterology·Hideki SuzukiColm O'Morain
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Sung Jae Shin, Michael T Collins
Jan 6, 2009·Journal of Gastroenterology and Hepatology·Hitoshi AsakuraToshio Morizane
May 15, 2009·Alimentary Pharmacology & Therapeutics·T YamamotoA R Saniabadi
Mar 31, 2010·Expert Review of Gastroenterology & Hepatology·Amy C Brown, Minakshi Roy
Dec 29, 2010·International Journal of Inflammation·Michael Scharl, Gerhard Rogler
Feb 18, 2011·Public Health Nutrition·Asim MaqboolVirginia A Stallings
Mar 31, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mazen Issa, Kia Saeian
Apr 14, 2012·Journal of Gastroenterology and Hepatology·Lani PrideauxSiew C Ng
May 10, 2012·Journal of Nutrition and Metabolism·E PattersonC Stanton
Nov 29, 2011·Molecular Nutrition & Food Research·Karen WindeyKristin Verbeke
Aug 4, 2012·Journal of Clinical Gastroenterology·Laura GitlinJordana Campbell
Sep 4, 2012·Current Gastroenterology Reports·Fergus Shanahan
Jan 31, 2013·Journal of Crohn's & Colitis·Carol L RobertsJonathan M Rhodes
Aug 15, 2017·Frontiers in Immunology·Donjete StatovciSilvia Melgar
Apr 3, 2020·Nutrients·Maria Chiara MentellaGiacinto Abele Donato Miggiano
Oct 3, 2020·Nutrients·Hannah MortonJane Coad
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·K MayerF Grimminger
Jul 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christian A HudertJing X Kang
Jul 26, 2005·European Journal of Nutrition·Helmut GrimmPeter Fürst
Nov 28, 2008·Alimentary Pharmacology & Therapeutics·G RomanatoE Manzato
Jun 1, 2006·Nutrition Research Reviews·Graham C Burdge, Philip C Calder
Jan 16, 2007·Internal Medicine·Toshifumi Hibi, Haruhiko Ogata
Jun 19, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·James W Fetterman, Martin M Zdanowicz
May 7, 2009·World Journal of Gastroenterology : WJG·Alfredo José Lucendo, Livia Cristina De Rezende
Oct 31, 2006·World Journal of Gastroenterology : WJG·Toshihito KosakaTakahiko Katoh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.