Epidemiologic and laboratory findings from 3 years of testing United States blood donors for Trypanosoma cruzi

Transfusion
Brian CusterMichael P Busch

Abstract

At most blood centers in the United States routine testing of donations for Trypanosoma cruzi using an enzyme-linked immunosorbent assay (ELISA) is followed by supplemental testing by radioimmunoprecipitation assay (RIPA). The objective of this study was to report the results of routine testing and risk factor data from allogeneic blood donors. T. cruzi testing data from January 2007 through December 2009 were analyzed, and risk factor interviews and follow-up studies were conducted on seroreactive donors. Prevalences of confirmed infection and risk factors associated with infection were assessed using logistic and multivariable logistic regression. Of 2,940,491 allogeneic donations from 1,183,076 donors, 305 (0.01% per donation tested and 0.026% per blood donor) were repeat reactive (RR) and 89 of those were confirmed positive by RIPA, yielding an overall seroprevalence of 1 per 33,039 donations and 1 per 13,292 donors. Country of birth and US blood center location differences in the seroprevalence of T. cruzi were evident. The odds of confirmed infection were highest if the donor reported having been bitten by the reduviid (kissing) bug (odds ratio [OR], 76.1; 95% confidence interval [CI], 11.1-3173) followed by having lived ...Continue Reading

References

Mar 1, 1996·Transfusion·S A Galel, L V Kirchhoff
Oct 23, 1997·The Journal of Infectious Diseases·D A LeibyR Y Dodd
Jun 19, 2003·The American Journal of Tropical Medicine and Hygiene·Myrna VirreiraMichal Svoboda
Feb 5, 2004·Journal of the American Dietetic Association·Jane WhiteUNKNOWN ADA Member Recognition Task Force
Dec 7, 2006·Postgraduate Medical Journal·A R L TeixeiraC A Santos-Buch
Feb 27, 2007·Transfusion·Carolyn YoungEdwin Forman
Jun 8, 2007·Emerging Infectious Diseases·Patricia L DornDawn Wesson
Sep 25, 2007·Memórias do Instituto Oswaldo Cruz·Gabriel A Schmunis
Dec 6, 2007·Memórias do Instituto Oswaldo Cruz·José Rodrigues Coura
Nov 15, 2007·JAMA : the Journal of the American Medical Association·Caryn BernAnne C Moore
Jul 1, 2008·The Journal of Infectious Diseases·David A LeibyBarbara L Herwaldt
Aug 30, 2008·Current Opinion in Infectious Diseases·Caryn BernSusan L Stramer
Nov 6, 2008·Tropical Medicine & International Health : TM & IH·Celia Regina FuruchóMaria A Shikanai-Yasuda
Dec 6, 2008·Transfusion Medicine Reviews·Brian Custer, Jeffrey S Hoch
Apr 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heather KunUNKNOWN Chagas Disease in Transplant Recipients Investigation Team
Jul 31, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caryn Bern, Susan P Montgomery
May 25, 2010·Transfusion·Maria AgapovaBrian Custer
Jun 26, 2010·Transfusion·Ester C SabinoUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component

❮ Previous
Next ❯

Citations

Jul 16, 2014·Current Opinion in Infectious Diseases·Evan P KransdorfJon A Kobashigawa
Aug 30, 2014·Epidemiology and Infection·M N GarciaK O Murray
Feb 9, 2013·Circulation·Ester C SabinoUNKNOWN National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II), International Component
Jan 19, 2016·Acta Tropica·Erin E ConnersKimberly C Brouwer
Sep 6, 2012·Transfusion·Jay E MenitoveGraham Sher
Sep 17, 2013·Transfusion·Jay S EpsteinHarvey G Klein
Oct 24, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K M U GuiangE Blodget
Apr 18, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Victor Augusto M GomesRoberto M Saraiva
Jul 8, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Pedro Emmanuel Alvarenga Americano do BrasilJosé Ueleres Braga
Nov 6, 2014·The American Journal of Tropical Medicine and Hygiene·Melissa N GarciaKristy O Murray
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheba K MeymandiMahmoud Traina
Nov 27, 2018·Transfusion·Yusuke SayamaMasahiro Satake
Feb 28, 2019·Blood·Michael P BuschSteven Kleinman
Jan 31, 2018·Transplantation·Lígia Camera PierrottiRogelio López-Vélez
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Erin E ConnersKimberly C Brouwer
Feb 21, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Léa Campos de OliveiraEster Cerdeira Sabino

❮ Previous
Next ❯

Related Concepts