PMID: 8940322Dec 4, 1996Paper

Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships

JAMA : the Journal of the American Medical Association
T C QuinnA Rompalo

Abstract

To determine the frequency of Chlamydia trachomatis genital infection within sexual partnerships using highly sensitive polymerase chain reaction (PCR) amplification and to identify the variables that might modify transmission. Cross-sectional study of sexual partnerships comparing in vitro culture and PCR amplification for C trachomatis. Two outpatient sexually transmitted disease clinics. Four hundred ninety-four people in sexual partnerships attending sexually transmitted disease clinics. Genital infection with C trachomatis. DNA sequencing was performed to examine specific genotypes within and between partnerships. Cross-sectional analysis was performed to determine characteristics associated with concordance or discordance of infection with partnerships. Cultures were positive for C trachomatis in 8.5% of males and 12.9% of females (P=.03). Using PCR, more infections were identified both in males (14.2%) and in females (15.8%), and the difference in infection rates analyzed by sex was no longer significant. In 20.4% of 494 couples, at least 1 partner had PCR results positive for C trachomatis, with a concordant infection rate of 10.7%, significantly higher than the 5.5% concordant infection rate demonstrable by culture (P<...Continue Reading

Citations

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