Epidemiologic Associations Between Short-Bowel Syndrome and Bloodstream Infection Among Hospitalized Children

Journal of the Pediatric Infectious Diseases Society
Benjamin A MikoElaine L Larson

Abstract

Children with short bowel syndrome (SBS) suffer from strikingly high rates of morbidity and mortality, due in part to their susceptibility to life-threatening infectious diseases. Few large, multisite studies have evaluated patient-specific factors associated with bacteremia in hospitalized children with and without SBS. We conducted a case-control study to examine the epidemiological associations between SBS and bloodstream infections (BSI) in hospitalized children. Pediatric BSI cases and controls were selected from a prospective cohort study conducted at 3 New York City hospitals. Among 40 723 hospital admissions of 30 179 children, 1047 diagnoses of BSI were identified. A total of 64 children had a diagnosis of SBS. BSI was identified frequently among hospitalizations for children admitted with SBS (n = 207/450, 46%) compared to hospitalizations for children without the condition (n = 840/40 273, 2.1%, P < .001). While this population represented only 0.2% of our overall cohort, it accounted for nearly 20% of all hospital admissions with BSI. Multivariable analysis identified 8 factors significantly associated with pediatric hospitalizations with BSI. These included a diagnosis of SBS (odds ratio [OR] 19.0), ages 1-5 years ...Continue Reading

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Citations

Apr 16, 2016·Early Human Development·Kelsey D J Jones, Lucy J Howarth
Apr 2, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Lori A DuesingAmy J Wagner
Dec 19, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jason G LakeIsaac See
Jun 11, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Talal B SeddikHayley Gans
May 7, 2019·Frontiers in Pediatrics·Assylzhan MessovaJutta Köglmeier
Dec 27, 2019·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Taylor WheatonMonica L Koncicki
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Augusto Lauro, Florence Lacaille
Jun 29, 2017·Pediatric Surgery International·Allison F LindenA Alfred Chahine
Nov 27, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Raouf NassarBaruch Yerushalmi
Jun 3, 2020·NeoReviews·Holly J Engelstad, Melissa E Danko

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