Epidemiologic characteristics associated with ST23 clones compared to ST1 and ST47 clones of Legionnaires disease cases in France

New Microbes and New Infections
P CassierSophie Jarraud

Abstract

In France, approximately 1200 cases of Legionnaires disease (LD) are reported annually, and isolates are available for approximately 20% of cases identified since 2000. All Legionella pneumophila serogroup 1 (sg1) isolates are characterized by sequence-based typing at the National Reference Centre. LD cases caused by L. pneumophila sg1 reported from 2008 through 2012 were considered for the study. Our study objective was to describe cases according to their sequence type (ST). We also constructed multivariable modified Poisson regression models to estimate the incidence rate ratio (IRR) and to identify characteristics potentially associated with ST23 clones compared to ST1 and ST47 clones. We studied 1192 patients infected by ST1 (n = 109), ST23 (n = 236), ST47 (n = 123) or other STs (n = 724). The geographic distribution of the ST23 cases across the country was significantly different compared to other ST groups. This genotype was significantly associated with the absence of corticosteroid therapy compared to ST1 (IRR = 0.56; p 0.016). Concerning exposure, the ST23 genotype was significantly less associated with hospital-acquired infections compared to ST1 (IRR = 0.32; p 0.001), but it was more associated with infections acqui...Continue Reading

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Citations

Feb 13, 2016·BMC Infectious Diseases·Ariela LevcovichMiriam Weinberger
Aug 11, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P CassierP Vanhems
Feb 28, 2015·Médecine et maladies infectieuses·C CampèseS Jarraud
Feb 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophia DavidJulian Parkhill
Jul 8, 2018·Applied and Environmental Microbiology·Junko Amemura-MaekawaUNKNOWN Working Group for Legionella in Japan
Apr 21, 2018·Scientific Reports·Sara QueroMarian Garcia-Núñez
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Sep 17, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C GinevraUNKNOWN ESCMID Study Group for Legionella Infections (ESGLI)

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