Epidemiologic design and analysis for proteomic studies: a primer on -omic technologies

American Journal of Epidemiology
Harald MischakJohn P A Ioannidis

Abstract

Proteome analysis is increasingly being used in investigations elucidating the molecular basis of disease, identifying diagnostic and prognostic markers, and ultimately improving patient care. We appraised the current status of proteomic investigations using human samples, including the state of the art in proteomic technologies, from sample preparation to data evaluation approaches, as well as key epidemiologic, statistical, and translational issues. We systematically reviewed the most highly cited clinical proteomic studies published between January 2009 and March 2014 that included a minimum of 100 samples, as well as strategies that have been successfully implemented to enhance the translational relevance of proteomic investigations. Limited comparability between studies and lack of specification of biomarker context of use are frequently observed. Nevertheless, there are initial examples of successful biomarker discovery in cross-sectional studies followed by validation in high-risk longitudinal cohorts. Translational potential is currently hindered, as limitations in proteomic investigations are not accounted for. Interdisciplinary communication between proteomics experts, basic researchers, epidemiologists, and clinician...Continue Reading

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Citations

Oct 23, 2015·Expert Review of Molecular Diagnostics·Maria FrantziHarald Mischak
Nov 13, 2015·Expert Review of Proteomics·Claudia FredoliniJochen M Schwenk
Dec 3, 2015·American Journal of Epidemiology·Muin J Khoury
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Nov 10, 2018·Expert Review of Proteomics·Maria FrantziHarald Mischak
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Feb 6, 2017·Bladder Cancer·Maria Frantzi, Antonia Vlahou

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