Epidemiologic features of infantile spasms in Slovenia

Epilepsia
Zvonka Rener PrimecDavid Neubauer

Abstract

To determine the epidemiologic features of infantile spasms (ISs) in Slovenia. Medical records of all children with ISs in Slovenia in the period from 1985 to 1995, based on community pediatrician referrals to four hospitals, including all pediatric EEG laboratories, were retrospectively studied. The outcome was assessed by a follow-up study in 1998. Forty-seven children with ISs were identified over an 11-year interval. The cumulative incidence was 2.06 per 10,000 live births. Among 29 (61.7%) children with symptomatic etiology, 14 cases had prenatal etiology [tuberous sclerosis (TS), seven; vascular insult, three; cerebral malformations, three; Down syndrome, one child], 14 perinatal and one postnatal cause: anoxic brain damage after cardiac surgery. Cryptogenic and idiopathic etiology were diagnosed in 13 (27.6%) and five (10.6%) of 47 cases, respectively. The age of onset of ISs ranged from 2 to 10 months. As initial treatment, steroids were used in 19 children (remission in 10); vigabatrin in seven (remission in four), and other antiepileptic drugs (AEDs) in 20 children (remission in six). According to the follow-up study, 18 (38.3%) children were seizure free, and 14 of them had normal mental development. Among 29 mentall...Continue Reading

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Citations

Apr 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Cohen-SadanH Goldberg-Stern
Aug 16, 2012·European Journal of Pediatrics·Stéphane AuvinLuigi Titomanlio
Jun 23, 2011·Current Medical Research and Opinion·Lindsay HallettJoice Valentim
Nov 26, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·A HrastovecD Neubauer
Aug 31, 2006·Pediatric Neurology·Zvonka Rener-PrimecDavid Neubauer
Nov 30, 2018·Orphanet Journal of Rare Diseases·Jason L JiaMiguel A Cortez
Dec 25, 2019·Seizure : the Journal of the British Epilepsy Association·Matthew B HunterRichard F M Chin

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