Epidemiologic Studies Cannot Reveal the True Shape of the Dose-Response Relationship for Radon-Induced Lung Cancer

Dose-response : a Publication of International Hormesis Society
Bobby R Scott

Abstract

A long-standing controversy is the correct shape of the dose-response relationship for lung cancer induction by inhaled radon (eg, residential radon) at low levels. A probabilistic approach is used in this commentary to show that cohort and case-control epidemiologic studies cannot reveal the true shape of the dose-response relationship for radon-induced lung cancer. Using the indicated approach, it is found that while the dose response for radon-induced lung cancer is expected to be threshold-increasing, the dose-response curve for the cancer incidence when cancers caused by smoking and other carcinogens are included is expected to be threshold-decreasing (ie, threshold-hormetic), as low-level radon can protect from cancer induction by other carcinogens via stimulating the body's natural defenses against cancer. These defenses include DNA damage repair, removal of aberrant cells via apoptosis, suppression of cancer promoting inflammation, and anticancer immunity.

References

Mar 25, 2011·Dose-response : a Publication of International Hormesis Society·Richard E Thompson
Jan 1, 2011·Dose-response : a Publication of International Hormesis Society·Bobby R Scott
Dec 1, 2017·Journal of Radiation Research·Ludwik DobrzynskiJoanna Reszczynska
Jun 7, 2018·Dose-response : a Publication of International Hormesis Society·Bobby R Scott

❮ Previous
Next ❯

Citations

Jun 14, 2020·International Journal of Environmental Research and Public Health·Barry Mc CarronShane Colclough
Jul 9, 2020·Environmental Science and Pollution Research International·Yuliya SemenovaGeir Bjørklund
May 27, 2021·Dose-response : a Publication of International Hormesis Society·Maciej PylakLudwik Dobrzyński

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Epidemiology
Alberto Ruano-RavinaJuan Miguel Barros-Dios
Revue de pathologie générale et de physiologie clinique
C LAVILLE
© 2022 Meta ULC. All rights reserved