Epidemiologic studies of polyomaviruses and cancer: previous findings, methodologic challenges and future directions

Advances in Experimental Medicine and Biology
Dana E M Rollison

Abstract

Polyomavirus infection became the focus of epidemiologic studies of cancer several decades ago, soon after the discovery of simian virus 40 (SV40) in 1960 and its ability to induce tumors in experimentally infected animals in 1961. Between 1963 and 2003, eight case-control and eleven cohort studies investigated the possible associations between polyomavirus infection and multiple types of cancer, including lymphoma, brain tumors, and mesothelioma. Two of these studies included measures of infection with the human polyomaviruses, JC virus and BK virus. Overall, the results from these studies were mostly null, although limitations in study design and exposure assessment complicate their interpretation. This chapter includes a review of results from previous epidemiologic studies of polyomavirus infection and human cancer, discussion of the methodologic challenges in study design, and proposed future directions for epidemiologic research.

Citations

Apr 14, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Robert Saddawi-Konefka, John R Crawford
Dec 25, 2012·Emerging Infectious Diseases·Florante N Dela CruzPatricia A Pesavento
Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Bryan A BassigNathaniel Rothman
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Apr 30, 2009·Experimental Dermatology·Roland HoubenJürgen C Becker
Nov 13, 2015·Neurosurgical Review·Tihomir EftimovElitsa Encheva

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