PMID: 7545207Apr 1, 1995Paper

Epidemiologic survey and genetic analysis of endemic hepatitis C virus infection in a Japanese town with a high prevalence of hepatitis B virus carriers

Journal of Medical Virology
H TawarayaH Asakura

Abstract

Mass screening for hepatitis C virus antibody was carried out in 875 inhabitants (313 men and 562 women) of a town in Japan with a high rate of hepatitis B virus infection. The overall rate of positivity for anti-HCV was 8.8% (6.4% in men and 10.1% in women). The rate of positivity for hepatitis B virus surface antigen was 11.2%. Five subjects (0.6%) were positive for both markers. HCV-RNA was detected in 65 (88.4%) of 77 individuals who were positive for anti-HCV and in 1 (1.5%) of 60 individuals negative for anti-HCV. The genotype of the HCV genome was determined by PCR analysis using type-specific primers in 60 individuals. HCV type 1b was detected in 51 subjects (85%), type 2a in 3 subjects (5%), and type 2b in 6 subjects (10%). None of the individuals was infected with more than one genotype. The nucleotide sequences of the partial nonstructural 5 region of HCV type 1b genotype obtained from 6 individuals showed at least 92.0% homology in the nucleotide sequence, and 94.8% homology in the amino acid sequence. Homology among these clones was greater than their homology with previously described type 1b sequences. The findings suggest that there was a specific local origin of HCV infection, although it was not possible to id...Continue Reading

References

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Citations

Jan 4, 2001·Microbes and Infection·S BellentaniC Tiribelli
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·William SievertFrancesco Negro
Feb 20, 2002·Journal of Viral Hepatitis·A OkayamaH Tsubouchi
Jan 13, 2012·Journal of Clinical Microbiology·Hyeokjin LeeDoo-Sung Cheon
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Markus CornbergStefan Zeuzem
Apr 19, 2005·Journal of Medical Virology·S MejriK Dellagi

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