Epidemiological analysis and follow-up of human rhinovirus infection in children with asthma exacerbation

Journal of Medical Virology
Shouyan ZhengEnmei Liu

Abstract

To determine the prevalence of human rhinovirus (HRV) infection in children with acute asthma exacerbations, investigation of HRV viral load and severity of asthma exacerbations is also required. Nasopharyngeal aspirates and swabs were collected and assessed for respiratory viruses. HRV-positive samples were sequenced to identify types and determine viral load. Outpatients with asthma exacerbations underwent follow-up evaluations, their swabs were collected and clinical outcomes were recorded at their next clinic visit 4 weeks later. One hundred forty-three inpatients and 131 outpatients, including 88 patients with asthma exacerbations and 43 controls with stable asthma were recruited. HRV-A was mainly detected in September and February (45.5% and 33.3%, respectively), while HRV-C was mainly detected in November and April (70.0% and 55.6%, respectively). HRV-C was the primary type and was primarily found in inpatients with severe asthma exacerbations. HRV-A viral load in the group of inpatients with severe exacerbations was higher than in the mild and moderate groups (P < 0.001 and P = 0.022). The HRV-A viral load of both inpatients and outpatients was higher than that of HRV-C (P < 0.001 and P = 0.036). The main genotypes were...Continue Reading

References

Mar 10, 1989·Cell·J M GreveA McClelland
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·F HoferD Blaas
Oct 8, 1998·The New England Journal of Medicine·F QureshiA Zaritsky
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·H E FlemingH A Boushey
Feb 5, 2000·JAMA : the Journal of the American Medical Association·W P GlezenR B Couch
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·M Z NorzilaP G Gibson
Nov 4, 2000·Journal of Clinical Microbiology·W XuD D Erdman
Feb 15, 2001·The New England Journal of Medicine·W W Busse, R F Lemanske
Feb 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·W PELONW E PIERCE
Sep 14, 2004·American Journal of Respiratory and Critical Care Medicine·Jorge GarbinoLaurent Kaiser
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Neil W JohnstonMalcolm R Sears
Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tobias AllanderOlli Ruuskanen
Jul 4, 2007·Proceedings of the American Thoracic Society·Sebastian L Johnston
Jul 31, 2007·The Journal of Allergy and Clinical Immunology·Malcolm R Sears, Neil W Johnston
Aug 30, 2008·Journal of Clinical Microbiology·David KiangDavid P Schnurr
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Jul 8, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E Kathryn MillerNatasha B Halasa
Apr 16, 2010·The Journal of Allergy and Clinical Immunology·Jaime P OlenecJames E Gern
Jul 9, 2010·The Journal of General Virology·Peter SimmondsTapani Hovi
Aug 10, 2010·The European Respiratory Journal·J BizzintinoP N Le Souëf
May 2, 2012·Allergy, Asthma & Immunology Research·Woo Kyung Kim, James E Gern
May 16, 2012·Journal of Medical Virology·Aya TakeyamaMitsuaki Hosoya
Nov 14, 2012·The Journal of Allergy and Clinical Immunology·Jodell E LinderE Kathryn Miller
May 17, 2013·The Journal of General Virology·Chloe L McIntyrePeter Simmonds
Jul 28, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ina L LauingerCheuk Y W Tong
Jul 31, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S EspositoN Principi
Nov 10, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Naoko KiyotaHirokazu Kimura
Jan 30, 2014·American Journal of Respiratory and Critical Care Medicine·Joshua L KennedyPeter W Heymann
Feb 5, 2014·European Journal of Pediatrics·Simon B DrysdaleAnne Greenough
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Kazuyuki NakagomeJames E Gern
Jul 6, 2014·Influenza and Other Respiratory Viruses·Marthi A PretoriusMarietjie Venter
Nov 19, 2014·Pediatrics·Michael J LoeffelholzTasnee Chonmaitree
Dec 6, 2014·The Journal of Allergy and Clinical Immunology·Euan R ToveyGuy B Marks
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yury A BochkovJames E Gern

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Citations

Dec 19, 2018·American Journal of Respiratory and Critical Care Medicine·J Michael RamsahaiPeter A B Wark
Jun 30, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Nozomi AbeShunji Hasegawa
Jul 30, 2020·Expert Review of Respiratory Medicine·Yang Xi, John W Upham
Nov 30, 2019·Current Allergy and Asthma Reports·Evin HowardWanda Phipatanakul
Jan 1, 2019·Pediatric Allergy, Immunology, and Pulmonology·Darrell L DinwiddieJoshua L Kennedy
Jun 15, 2019·Viruses·Silvia VandiniMarcello Lanari
May 5, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Haruna KitazawaNobuyuki Hizawa
Apr 9, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Nidhya NavanandanAndrew H Liu
Jun 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Dillon Charles AdamJen Kok

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Datasets Mentioned

BETA
JN621242

Methods Mentioned

BETA
PCR

Software Mentioned

CLUSTAL W
MEGA5
MEGA

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