PMID: 8973032Oct 1, 1996Paper

Epidemiological analysis of prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc). Scleroderma Research Committee Japan

The Journal of Dermatology
K NishiokaJ Kaburagi

Abstract

For the first time, we performed an epidemiological study of SSc in Japan to study the factors influencing prognosis, survival rate and cause of death of Japanese SSc patients and to compare our data with those from foreign countries. Prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc) was analyzed based on clinical data described in case cards provided by the members of the Scleroderma Research Committee of the Japanese Ministry of Health and Welfare. The essential observation period was from 5 to 20 years, at ending in 1994. Ninety patients died (males 11, females 79). The age of onset of the deceased patients was significantly higher than that of surviving patients (deceased, 45.6 yrs, surviving 41.3 yrs). Statistically significant factors for a poor prognosis were as follows: Barnett type III > type II > type I, positive for anti-Scl-70 antibody, negative for anti-centromere antibody. The survival rate at 5 years after the onset of the disease was 0.937, followed by 0.82 at 10 years, 0.567 at 20 years and 0.40 at 30 years after the onset. Sex was not a predictor for prognosis, although male patients died at an earlier stage of the disease. The most common causes of death were heart failure, pulmonar...Continue Reading

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Citations

Aug 19, 2008·Seminars in Arthritis and Rheumatism·Firas F Al-DhaherJanine M Ouimet
Jan 29, 2008·Seminars in Arthritis and Rheumatism·Y Stephanie GuM Eric Gershwin
Jun 17, 2014·Seminars in Arthritis and Rheumatism·Manuel Rubio-RivasVicent Fonollosa
Sep 24, 2010·International Journal of Rheumatology·Kenichi NakajimaKazuhiko Takehara
Jun 5, 2007·Immunobiology·Grith Lykke SorensenUffe Holmskov
Feb 1, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Seiji Takeda
Feb 1, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Fumio SakauchiHideharu Endo
Sep 17, 2017·Cellular and Molecular Life Sciences : CMLS·Hiroyuki MurotaIchiro Katayama
Jul 19, 2011·The Journal of Rheumatology·Atsushi HashimotoShunsei Hirohata
Aug 17, 2012·The Journal of Rheumatology·Percival D Sampaio-BarrosJoão Francisco Marques-Neto
Jan 22, 2008·The British Journal of Dermatology·Y HamaguchiS Sato
Dec 4, 2009·Clinical Rheumatology·Jinhyun KimEun Bong Lee
Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
Jul 14, 2012·Internal Medicine·Atsushi HashimotoShunsei Hirohata
Apr 20, 2018·International Journal of Rheumatic Diseases·Gokhan SarginSongul Cildag
Mar 13, 2002·Medicine·Clodoveo FerriUNKNOWN Systemic Sclerosis Study Group of the Italian Society of Rheumatology (SIR-GSSSc)
Nov 8, 2020·International Journal of Clinical Practice·Hui ZhongXiaofeng Zeng
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Jul 15, 2021·Journal of Immunology Research·Shirin AssarJavier Echeverría

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