Epidemiological and clinical based study on four passages of COVID-19 patients: intervention at asymptomatic period contributes to early recovery

BMC Infectious Diseases
Xiaohong ZhangYi Wang

Abstract

With the worldwide spread of the 2019 novel coronavirus, scarce knowledge is available on the clinical features of more than two passages of patients. Further, in China, early intervention policy has been enacted since February. Whether early intervention contributes to swift recovery is still unknown. Hence, in this study, we focused on the patients from an isolated area, investigated the epidemiological and clinical characteristics of four serial passages of the virus. From January 25 to February 29, 2020, all patient data on the SARS-CoV-2 passages in this isolated area were traced, and the patients were grouped according to the passaging of SARS-CoV-2. Clinical characteristics of patients, including laboratory, radiology, treatment and outcomes, were collected and analyzed. A total of 78 patients with four passages of virus transmission were included in this study. One patient transmitted SARS-CoV-2 to 8 patients (passage 2, P2), who next infected 23 patients (passage 3, P3), and then 46 patients (passage 4, P4). P2 received antiviral treatment when they had symptom, whereas P4 received antiviral treatment during their asymptomatic period. The incubation periods for P2, P3 and P4 patients were 7 days (IQR:2-12), 8 days (IQR...Continue Reading

References

Feb 1, 2020·The New England Journal of Medicine·Camilla RotheMichael Hoelscher
Feb 7, 2020·Epidemiology and Health·Sukhyun RyuUNKNOWN Korean Society of Epidemiology 2019-nCoV Task Force Team
Feb 8, 2020·JAMA : the Journal of the American Medical Association·De ChangLokesh Sharma
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 18, 2020·Lancet·David L HeymannUNKNOWN WHO Scientific and Technical Advisory Group for Infectious Hazards
Feb 20, 2020·The New England Journal of Medicine·Marc LipsitchLyn Finelli
Feb 23, 2020·JAMA : the Journal of the American Medical Association·Yan BaiMeiyun Wang
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
May 15, 2020·The Journal of Pediatrics·Roberta L DeBiasiDavid Wessel

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Methods Mentioned

BETA
nucleic acid assay

Software Mentioned

SPSS ( Statistical Package for the Social Sciences )

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