Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan

PloS One
Reiko Shimbashiand the Adult IPD Study Group

Abstract

Enhanced surveillance of invasive pneumococcal disease (IPD) in adults was conducted during April 2013-March 2018 in 10 of 47 prefectures in Japan, and a total of 1277 IPD patients were enrolled. An emergence of IPD caused by serotype 12F was identified during May 2015-March 2018 through this surveillance. 12F isolates were composed of four related sequence types. In total, 120 patients with 12F IPD were reported during this period. To characterize the clinical features of 12F IPD, the disease characteristics of these patients were compared with those of 1157 patients with non-12F IPD. Compared with the non-12F IPD patients, a significantly lower proportion of 12F IPD patients was aged 65 years or older (55% vs. 70%), vaccinated with 23-valent pneumococcal polysaccharide (4% vs. 14%), had comorbid illness (65% vs. 77%), or were immunocompromised (19% vs. 30%; all P < 0.05). No significant difference in the proportion of case fatalities was found between the two groups. The proportions of those aged 65 years or older (53% vs. 69%) and with bacteremic pneumonia (35% vs. 69%) were significantly lower in 17 patients who died from 12F IPD than in 205 patients who died from non-12F IPD (all P < 0.05). Differences in clinical features...Continue Reading

References

Sep 8, 1994·The New England Journal of Medicine·C W HogeR F Breiman
Mar 2, 1994·JAMA : the Journal of the American Medical Association·T CherianJ Dick
Feb 21, 2004·The Journal of Infectious Diseases·A SandgrenB Henriques Normark
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Aug 10, 2006·The Journal of Infectious Diseases·Karen L SleemanTimothy E A Peto
Jun 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angelique G S C JansenEelko Hak
Jun 23, 2009·Epidemiology and Infection·N ChibaUNKNOWN IPD Surveillance Study Group
Sep 6, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alexey V RakovD Ashley Robinson
May 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erin SchillbergSalaheddin M Mahmud
Jun 19, 2015·Clinical Microbiology Reviews·K Aaron GenoMoon H Nahm
Oct 21, 2015·Emerging Infectious Diseases·Kimiko UbukataUNKNOWN Invasive Pneumococcal Diseases Surveillance Study Group
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xianding DengDylan R Pillai
Oct 20, 2018·Emerging Infectious Diseases·Kimiko UbukataUNKNOWN Invasive Pneumococcal Diseases Surveillance Study Group

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Citations

Sep 19, 2020·Emerging Infectious Diseases·Reiko ShimbashiUNKNOWN Adult IPD Study Group
Oct 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Katsunori YanagiharaMitsuo Kaku

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Methods Mentioned

BETA
PCR

Software Mentioned

Stata
eBURST

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