Epidemiological and laboratory characterization of a yellow fever outbreak in northern Uganda, October 2010-January 2011

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Joseph F WamalaAnthony K Mbonye

Abstract

In November 2010, following reports of an outbreak of a fatal, febrile, hemorrhagic illness in northern Uganda, the Uganda Ministry of Health established multisector teams to respond to the outbreak. This was a case-series investigation in which the response teams conducted epidemiological and laboratory investigations on suspect cases. The cases identified were line-listed and a data analysis was undertaken regularly to guide the outbreak response. Overall, 181 cases met the yellow fever (YF) suspected case definition; there were 45 deaths (case fatality rate 24.9%). Only 13 (7.5%) of the suspected YF cases were laboratory confirmed, and molecular sequencing revealed 92% homology to the YF virus strain Couma (Ethiopia), East African genotype. Suspected YF cases had fever (100%) and unexplained bleeding (97.8%), but jaundice was rare (11.6%). The overall attack rate was 13 cases/100000 population, and the attack rate was higher for males than females and increased with age. The index clusters were linked to economic activities undertaken by males around forests. This was the largest YF outbreak ever reported in Uganda. The wide geographical case dispersion as well as the male and older age preponderance suggests transmission du...Continue Reading

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Citations

Nov 20, 2013·Parasites & Vectors·Matthias BundschuhAlexander Gerber
Aug 6, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Matthew J CummingsBarnabas Bakamutumaho
Jun 10, 2014·The Journal of Clinical Investigation·Enoch MuyanjaDenis Gaucher
Oct 10, 2014·BMC Family Practice·Martin Kayitale MbonyeAllan Ronald
Oct 5, 2015·The Journal of Molecular Diagnostics : JMD·Martina I LefterovaBenjamin A Pinsky
Jan 23, 2017·Biochemical and Biophysical Research Communications·Marycelin Mandu Baba, Mayomi Ikusemoran
Jul 11, 2013·Current Opinion in Pediatrics·Saba JavedStephen K Tyring
Nov 6, 2018·BMC Infectious Diseases·Leocadia KwagonzaBao-Ping Zhu
Jul 17, 2019·The American Journal of Tropical Medicine and Hygiene·Jaques SztajnbokRalcyon Francis AzevedoTeixeira
Oct 20, 2017·International Journal of Health Economics and Management·Mario Songane
May 28, 2020·The American Journal of Tropical Medicine and Hygiene·Lena HueblRuth Kutalek
Dec 12, 2018·PLoS Neglected Tropical Diseases·Brecht IngelbeenBenoît I Kebela
Aug 24, 2018·Genes·Raphaëlle KlittingXavier de Lamballerie
Mar 25, 2015·AIMS Public Health·Hamdi Abdulwahab AlhakimiWaled Amen Ahmed
Jun 13, 2018·Genes·Raphaëlle KlittingXavier de Lamballerie
Jun 1, 2019·Journal of Travel Medicine·Yeh-Li HoUNKNOWN Hospital das Clínicas Yellow Fever Assistance Group
Mar 25, 2021·Health & Social Care in the Community·Prince C I UmokeCharity C Okide
Jun 25, 2021·The Journal of General Virology·Martin N MayanjaAlain Kohl
Aug 18, 2021·BMC Infectious Diseases·Joseph L ServadioMatteo Convertino
Oct 6, 2021·The Journal of General Virology·Martin N MayanjaAlain Kohl

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