Epidemiological characterisation of Streptococcus pneumoniae from India using multilocus sequence typing

Indian Journal of Medical Microbiology
T GopiV Balaji

Abstract

The aim of this study was to utilize the multilocus sequence typing (MLST) technique to characterise Streptococcus pneumoniae among clinical isolates in India. MLST was used to determine clonality, to establish genetic relatedness, to check for correlation between serotypes and sequence types (STs) and its relevance associated with antibiotic resistance. Forty consecutive invasive S. pneumoniae isolates in children<5 years were characterised. Preliminary identification of serotype and antibiotic susceptible profile was followed with MLST technique to identify the STs of the isolates. STs were then analysed for clonality using an eBURST algorithm and genetic relatedness using Sequence Type Analysis and Recombinational Tests version 2 software. The most common ST was ST63. Among the forty isolates, we identified nine novel STs, six of which had known alleles but in new combinations, three of which had new alleles in their sequence profile. The new STs assigned were 8501-8509. One clonal complex was found among the 40 strains characterised. The most common serotypes in this study were serotype 19F, 14 and 5. Non-susceptibility to penicillin and erythromycin was observed in 2.5% and 30% of the isolates, respectively. This study sho...Continue Reading

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Citations

Sep 10, 2017·Indian Journal of Pediatrics·Aaradhana Singh, A K Dutta
Dec 18, 2018·Expert Review of Clinical Immunology·Casandra Buzatu, Robert J Moots
Jul 28, 2019·The Laryngoscope·László RovóÁdám Bach
Sep 23, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kara D MeisterMichael J Brenner
Mar 19, 2019·Indian Journal of Medical Microbiology·Anand Manoharan, Ranjith Jayaraman

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