Epidemiological Characterization of the 2017 Dengue Outbreak in Zhejiang, China and Molecular Characterization of the Viruses

Frontiers in Cellular and Infection Microbiology
Hao YanYanjun Zhang

Abstract

Dengue, a mosquito-borne disease caused by the dengue virus (DV), has been recognized as a global public health threat. In 2017, an unexpected dengue outbreak occurred in Zhejiang, China. To clarify and characterize the causative agent of this outbreak, data on dengue fever cases were collected from the China Information System for Disease Control and Prevention in Zhejiang province for subsequent epidemiological analysis. A total of 1,229 cases were reported, including 1,149 indigenous and 80 imported cases. Most indigenous cases (1,128 cases) were in Hangzhou. The epidemic peak occurred in late August and early September, and the incidence rate of elderly people (4.34 per 100,000) was relatively high. Imported cases were reported all year round, and most were from South-East Asia and Western Pacific regions. Young people and men accounted for a large fraction of the cases. Acute phase serums of patients were collected for virus isolation. And 35 isolates (including 25 DV-2, 8 DV-1, 1 DV-3, and 1 DV-4) were obtained after inoculation and culture in mosquito C6/36 cells. The E genes of the 35 new DV isolates and the complete genome of a DV-2 isolate (Zhejiang/HZ33/2017), and the E gene of a DV-2 isolate from Ae. albopictus (Zhe...Continue Reading

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Citations

Mar 3, 2020·Japanese Journal of Infectious Diseases·Chuan GuoChangwen Ke
Oct 13, 2020·Journal of Travel Medicine·Yingying MaChiyu Zhang
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Yuan FangYi Zhang
Jul 1, 2021·Scientific Reports·Surya Pavan YenamandraHapuarachchige Chanditha Hapuarachchi
Jul 9, 2021·Reviews in Medical Virology·Tiantian WuYi-Ping Li
Aug 24, 2021·Vector Borne and Zoonotic Diseases·Jonas NäslundOlivia Wesula Lwande
Aug 28, 2021·Tropical Medicine and Infectious Disease·Hisham A ImadTatsuo Shioda

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Datasets Mentioned

BETA
MH010595
AY835999

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

MEGA
LaserGene
ArcGIS
SEQMAN
R
Clustal W

Related Concepts