Abstract
Disseminated tuberculosis (TB) accounts for 1 to 3% of all TB cases. This retrospective study reviews the clinical, radiological, laboratory findings and outcome in patients with disseminated tuberculosis in an endemic area. Medical records were reviewed for patients with disseminated TB admitted to two tertiary centers in Tehran, Iran between 1999 and 2006. Fifty patients were found to have disseminated TB. A miliary pattern was documented in the chest x-ray of 34 patients. Hematologic abnormalities including anemia, leukopenia, and thrombocytopenia were frequently observed. Death occurred in nine of the cases. The mortality rate was significantly higher in diabetic patients, injection drug users, and patients with hematologic abnormalities; however, steroid usage and human immunodeficiency virus infection were not significantly associated with a higher mortality rate. Clinical improvement occurred in 41 patients following treatment. Disseminated TB could have different manifestations. Hematologic abnormalities are common and are considered poor prognostic signs in these patients.
References
Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P H Kazanjian
Jul 1, 1990·Reviews of Infectious Diseases·J H KimH A Gallis
Sep 1, 1990·The American Journal of Medicine·G MaartensS R Benatar
Nov 1, 1993·Survey of Ophthalmology·C J Helm, G N Holland
Jun 1, 1993·Journal of Clinical Gastroenterology·J SeabraA Rocha-Marques
Aug 1, 1996·Chest·J S KwongJ M FitzGerald
Nov 24, 1999·AIDS·C F von Reyn
Jan 15, 2000·The British Journal of Ophthalmology·D MileaP Lehoang
Sep 14, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·A MertY Aktuglu
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Crump, L Barth Reller
Jul 14, 2004·Neurology·Douglas J Lanska
Jan 18, 2006·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Giselle Burlamaqui Klautau, Tuba M Kuschnaroff
Aug 21, 1948·British Medical Journal·R S ILLINGWORTH, T WRIGHT
Citations
Apr 14, 2011·Journal of Clinical Immunology·Payam TabarsiDavood Mansouri
Jul 5, 2011·BMC Medicine·Meghan A BakerMegan B Murray
May 24, 2011·Immunobiology·Pedro N RodriguesM Salomé Gomes
Mar 25, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J HassingP J van Genderen