PMID: 8938199Nov 4, 1996Paper

Epidemiological data suggest antidepressants reduce suicide risk among depressives

Journal of Affective Disorders
G IsacssonC L Rich

Abstract

In spite of the availability of antidepressant medication for several decades, it has not been shown that such medication lowers the risk for suicide in depressed patients. This report explores this apparent paradox by means of pharmacoepidemiological methods. Data on the prevalence of depression in the population and among suicides as well as data on the prevalence of antidepressant medication in depressed suicides were obtained from a review of the literature. Data on the prevalence of antidepressant medication in the population in 1990-1991 were obtained from the statistics of the Swedish National Corporation of Pharmacies. It was found that only one in five depressed individuals with major depression were treated with antidepressants in Sweden. The calculated risk for suicide among depressed patients who were treated with antidepressants was 141 per 100,000 person years and, among the untreated, 259 per 100,000 person years (i.e., 1.8 times higher among the untreated). This supports the hypothesis that antidepressant medication decreases the risk for suicide in depressed patients. The reason this has not been obvious in the general suicide statistics seems to be that so few depressed people are treated with antidepressants....Continue Reading

References

Jan 1, 1978·Neuropsychobiology·O Hagnell, B Rorsman
Jun 1, 1978·Archives of General Psychiatry·D Avery, G Winokur
Feb 1, 1975·Psychological Medicine·B M Barraclough, D J Pallis
Mar 1, 1992·Journal of Clinical Epidemiology·U Bergman
Aug 1, 1990·Acta Psychiatrica Scandinavica·U Asgård
Feb 1, 1990·The American Journal of Psychiatry·M H TeicherJ O Cole
Apr 1, 1988·Acta Psychiatrica Scandinavica·M AratóE Somogyi
Jun 1, 1986·Archives of General Psychiatry·C L RichR C Fowler
Aug 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson
Oct 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·B BarracloughP Sainsbury
Jan 1, 1984·Acta Psychiatrica Scandinavica·T Hällström
Mar 1, 1983·Archives of General Psychiatry·G E Murphy
Mar 1, 1980·The Australian and New Zealand Journal of Psychiatry·R ChynowethJ Armstrong
Jul 1, 1995·Archives of General Psychiatry·A T Cheng
Jan 14, 1995·BMJ : British Medical Journal·G IsacssonU Bergman
Jan 28, 1995·BMJ : British Medical Journal·J G Edwards
Dec 1, 1994·Journal of Affective Disorders·G IsacssonC L Rich
May 7, 1994·BMJ : British Medical Journal·D Gunnell, S Frankel
Feb 19, 1994·BMJ : British Medical Journal·G IsacssonU Bergman
Jul 1, 1959·American Journal of Public Health and the Nation's Health·E ROBINSJ KAYES
Dec 1, 1960·Comprehensive Psychiatry·T L DORPAT, H S RIPLEY

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Citations

May 24, 2011·Social Psychiatry and Psychiatric Epidemiology·Valerie J Callanan, Mark S Davis
Jun 20, 2006·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Nov 12, 2003·Current Psychiatry Reports·Yves Lecrubier
Dec 4, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Christopher B KellyMike Stevenson
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Asher B Simon, Jack M Gorman
Jun 9, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Florin A OrhaPierre Baumann
Jul 14, 1999·Journal of Affective Disorders·G StoppeJ Staedt
Dec 1, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·A P Boardman, D Healy
Dec 1, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·Z Rihmer
Mar 9, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R FreyS Kasper
Jan 27, 2006·International Clinical Psychopharmacology·Stuart A Montgomery
Jun 24, 2004·The Australian and New Zealand Journal of Psychiatry·Peter Ellis, UNKNOWN Royal Australian and New Zealand College of Psychiatrists Clinical Practice Guidelines Team for Depression
Jul 30, 2005·The Australian and New Zealand Journal of Psychiatry·Theo VosGavin Andrews
May 14, 2003·BMJ : British Medical Journal·Wayne D HallPeter McManus
Jan 15, 2010·Annual Review of Public Health·Robert D GibbonsJ John Mann
May 1, 2001·Suicide & Life-threatening Behavior·A Roy
Aug 30, 2014·American Journal of Epidemiology·Sean A P CloustonBruce G Link
Aug 26, 2014·American Journal of Preventive Medicine·Joshua J GriffithsJ J Rasimas
Dec 19, 1998·Journal of Affective Disorders·A OhbergJ Lonnqvist
Sep 23, 1997·Journal of Affective Disorders·C L Rich, G Isacsson
Jan 11, 2000·Journal of Affective Disorders·G W Blair-WestM L Eyeson-Annan
Feb 15, 2001·Journal of Affective Disorders·W Rutz
Jun 14, 2002·Journal of Affective Disorders·F AngstJ Angst
Dec 21, 2006·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Mao-Sheng RanYeates Conwell
Jun 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Göran IsacssonMelissa Raven
Oct 5, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Dan SiskindJane Kim
Aug 22, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·U HeppV Ajdacic-Gross
Apr 6, 2006·Emergency Medicine Clinics of North America·Joanna Piechniczek-Buczek
Nov 4, 2004·Acta Psychiatrica Scandinavica·B I YerevanianJ Mintz
Sep 6, 2003·Acta Psychiatrica Scandinavica. Supplementum·H J Möller
Aug 24, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Andrew C LeonSandro Galea
Nov 8, 2006·Suicide & Life-threatening Behavior·J T MaltsbergerR Tatarelli
Feb 1, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Benjamas PrukkanoneStephen Lim
Oct 1, 2005·International Review of Psychiatry·Göran Isacsson, Charles L Rich
Aug 22, 2008·Crisis·Ana SfoggiaRodrigo Grassi-Oliveira
Jun 22, 2013·Journal of Psychiatric Research·Steven J GarlowMark Hyman Rapaport
Jan 1, 1998·Nutritional Neuroscience·C A AmendolaH R Lieberman
Sep 2, 2004·The Annals of Pharmacotherapy·Patrick R Finley
Jan 1, 1999·International Journal of Psychiatry in Clinical Practice·J Q BosticJ Biederman
Sep 23, 2006·Harvard Review of Psychiatry·Joel Paris
Nov 11, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·David Althaus, Ulrich Hegerl
Nov 11, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Herman M Van Praag

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