Epidemiological evidence for immunity following Trypanosoma brucei gambiense sleeping sickness

Transactions of the Royal Society of Tropical Medicine and Hygiene
N KhondeP De Wals

Abstract

In order to investigate whether protective immunity appears after Trypanosoma brucei gambiense sleeping sickness, we undertook a retrospective cohort study of 3 remote villages in central Zaire (total population 1431), in which 38% of all adults had a past history of human African trypanosomiasis. Among adults previously diagnosed with trypanosomiasis and treated, the risk of a second episode of trypanosomiasis during the 10 years period of observation was only 15% (with a 24 months refractory period) and 30% (without a refractory period) of the risk of a first episode in adults never previously diagnosed. We could not demonstrate a similar difference among children, to some extent because only a few of them were diagnosed for a first time with trypanosomiasis. Our findings suggest that very significant immunity appears after Gambian sleeping sickness, and that developing a vaccine against this subspecies of trypanosomes is biologically plausible.

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Citations

May 17, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
Dec 25, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jacques PépinMasasa Iloasebe
Feb 17, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·N KhondeP De Wals
Nov 23, 1996·Lancet·M EkwanzalaP De Wals
Dec 12, 2001·Tropical Medicine & International Health : TM & IH·A FischerD Steverding
May 10, 2002·Tropical Medicine & International Health : TM & IH·A GarciaC Laveissière
Dec 1, 2006·Proceedings. Biological Sciences·Robert J Quinlan
Jul 14, 2006·Trends in Parasitology·André GarciaVincent Jamonneau
May 25, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Philippe Vincendeau, Bernard Bouteille
May 10, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J P Gouteux, M Artzrouni

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African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

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