PMID: 8949972Oct 1, 1996Paper

Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus

Annals of Medicine
M Laakso, J Kuusisto

Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) increases the risk for all manifestations of atherosclerotic vascular disease, coronary heart disease (CHD), cerebrovascular disease and peripheral vascular disease. Only a small proportion of this excess risk can be explained by the effects of conventional cardiovascular risk factors, which implies that the diabetic state or factors related to it have to play a significant role in the pathogenesis of macrovascular disease in NIDDM. Six recent prospective population-based studies including a large number of NIDDM patients have indicated that poor glycaemic control evaluated by fasting hyperglycaemia or glycosylated haemoglobin levels increases the risk for CHD, stroke and amputation independently of other risk factors. A dose-response relationship between markers of glycaemic control and the incidence of cardiovascular mortality and morbidity has been demonstrated in all these studies. However, there is so far no direct proof that strict glycaemic control would delay or prevent atherosclerotic complications.

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Citations

Aug 10, 1999·Diabetes/metabolism Research and Reviews·S H WildS Comte
Mar 2, 2002·Journal of Diabetes and Its Complications·Alain D Baron
Mar 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalie Rasgon, Lissy Jarvik
Sep 24, 2010·International Journal of Clinical Practice·A Ceriello
Aug 10, 1999·Scandinavian Journal of Primary Health Care·P E Wändell
Apr 7, 2009·Taiwanese Journal of Obstetrics & Gynecology·Fang-Yi ChenHei-Jen Jou
Jun 10, 2004·Patient Education and Counseling·Barend J C Middelkoop, Gerrit van der Wal
Sep 2, 1999·Tropical Medicine & International Health : TM & IH·M A van der SandeK P McAdam
Jan 17, 2008·American Journal of Alzheimer's Disease and Other Dementias·Behnam SabayanAfshin Borhanihaghighi
Jun 26, 1999·European Journal of Clinical Investigation·D R Owens
Aug 2, 2008·Journal of Cardiovascular Pharmacology·Charles A Reasner
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·W Q LuB V Howard
Jan 12, 2019·Arthritis Research & Therapy·Zoltán SzekaneczWillem F Lems
Aug 16, 2000·Thrombosis Research·L R HernándezC L Arocha-Piñango

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