PMID: 8611390Mar 1, 1996Paper

Epidemiological evidence of cervical intraepithelial neoplasia without the presence of human papillomavirus

British Journal of Cancer
M P BurgerW G Quint

Abstract

The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between HPV-positive and HPV-negative patients. Patients at a gynaecological outpatient clinic of a university hospital [a total of 265 consecutive women with dyskaryotic cervical smears who were subsequently diagnosed with CIN I (n=37), CIN II (n=48) or CIN III (n=180)] completed a structured questionnaire regarding smoking habits and sexual history. Analysis of an endocervical swab for Chlamydia trachomatis, analysis of a cervical scrape for HPV, and morphological examination of cervical biopsy specimens were also performed. HPV was found in 205 (77.4%) out of the 265 women. Univariate analysis showed that current age (P=0.02), current smoking behaviour (P=0.002) and the number of sexual partners (P=0.02) were significantly associated with the presence of HPV. Age at first sexual intercourse, a past history of venereal disease or genital warts, and current infection with Chlamydia trachomatis were not associated with th...Continue Reading

Citations

Mar 24, 1999·Journal of the National Cancer Institute·E L FrancoL L Villa
Jun 23, 2000·Clinical Obstetrics and Gynecology·R H KaufmanV Vonka
Jun 20, 1998·Sexually Transmitted Infections·S A Southern, C S Herrington
Sep 3, 1998·Histopathology·C J MeijerJ M Walboomers
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·S N TabriziS M Garland
Jan 29, 2000·International Journal of Dermatology·R Wolf, D Freedman
Mar 15, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J BhaumikA E Davies
Apr 25, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·N S Murthy, A Mathew

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