Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise.

Gene Expression
Jia XiaoHua Wang

Abstract

Globally, alcohol consumption contributes to more than 3 million deaths each year. While much of its ramifications is preventable, a coherent public health discourse on how to limit alcohol-related harm has been overdue. By synthesizing information from national and global databases, we show in this analysis that alcohol consumption level and alcohol-attributable burden of diseases, particularly alcoholic liver disease (ALD), are intimately linked to national income distribution, cultural norms, religion, sex, age, and health status. Prevalence and burden of ALD are positively associated with economic standing in most countries, which necessitate active governmental control via cost-effective policies, such as the best buys proposed by the World Health Organization. To date, a number of critical questions remain unanswered over the molecular mechanisms underlying ALD pathophysiology; the insights gained thereof should provide new opportunities for the advancement of novel diagnostic and management strategies. In comparison with other prevailing liver diseases (e.g., viral hepatitis and nonalcoholic fatty liver disease), governmental support to ALD investigation has been sluggish in most Western countries and China, resulting in...Continue Reading

References

Nov 25, 2005·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindRalph L Sacco
Sep 25, 2010·American Journal of Public Health·Alexander C WagenaarKelli A Komro
May 22, 2013·Nature Reviews. Gastroenterology & Hepatology·Gyongyi Szabo, Shashi Bala
Mar 18, 2015·Nature Reviews. Gastroenterology & Hepatology·Alexandre Louvet, Philippe Mathurin
May 27, 2015·Gastroenterology·Arun J SanyalGyongyi Szabo
Mar 1, 2016·Gastroenterology·Suthat LiangpunsakulGeoffrey W McCaughan
May 8, 2016·Journal of Hepatology·Giovanni AddoloratoAntoni Gual
Jun 3, 2016·Alcoholism, Clinical and Experimental Research·Ashwani K SingalThomas D Schiano
Sep 3, 2016·Acta Neurologica Scandinavica·S JesseA C Ludolph
Feb 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sebastian MuellerThomas Longerich
Jun 20, 2017·The Lancet. Public Health·Srinivasa Vittal KatikireddiAlastair H Leyland
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Richard ParkerBin Gao
Jan 18, 2018·The American Journal of Gastroenterology·Ashwani K SingalVijay H Shah
Apr 3, 2018·Annual Review of Public Health·Marissa B Esser, David H Jernigan
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Apr 21, 2018·Lancet·Angela M WoodUNKNOWN Emerging Risk Factors Collaboration/EPIC-CVD/UK Biobank Alcohol Study Group
Nov 21, 2018·Clinics in Liver Disease·Brett StyskelFasiha Kanwal
Jan 3, 2019·Annual Review of Public Health·Frank J ChaloupkaKenneth E Warner
Jan 20, 2019·Journal of Hepatology·Bin GaoHidekazu Tsukamoto
Jan 20, 2019·Journal of Hepatology·Shiv K SarinBernd Schnabl
Jan 20, 2019·Journal of Hepatology·Christophe MorenoGyongyi Szabo
Jan 20, 2019·Journal of Hepatology·Nathalie Ganne-Carrié, Pierre Nahon
Jan 20, 2019·Journal of Hepatology·Carolin Lackner, Dina Tiniakos
Apr 24, 2013·Clinical Liver Disease·Neil Edward Crittenden, Craig McClain
May 8, 2019·JAMA : the Journal of the American Medical Association·Terrence WongRobert J Wong
May 28, 2019·Journal of Global Health·Charlotte ProbstJürgen Rehm
Sep 3, 2019·Addiction·Jürgen RehmMindaugas Štelemėkas
Sep 5, 2019·The New England Journal of Medicine·Ida Sim
Dec 17, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Michelle KozenieckiBrittney Patterson
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Meritxell Ventura-CotsRamon Bataller

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Citations

Aug 20, 2021·Frontiers in Neuroendocrinology·Mianhuan LiJia Xiao

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