Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer

Contact Dermatitis
Birger KränkeWerner Aberer

Abstract

Bufexamac-containing ointments and creams are widely used by many patients with eczematous disorders as an alternative to topical corticosteroids. Recent studies provide evidence of a notable prevalence of contact sensitization in patch test populations. The aim of this study was to assess the frequency of use of this topically-applied drug by eczema patients in general, and to evaluate its potential to cause allergic contact reactions. 500 routinely patch tested patients (f:m = 377:123) were tested with bufexamac 5% and Parfenac ointment (the only commercial product available in Austria) in addition to the standard and other series of the German Contact Dermatitis Group. The packaging of the commercial product was shown to the entire study population, to decide whether or not they had ever used this product. In addition, their general practitioner was contacted to verify the anamnestic data. A total of 30 patients agreed that they had definitely used bufexamac, 5 others having probably applied it. The indication for and the duration of treatment were noted. Positive and relevant patch test reactions to bufexamac, as well as the bufexamac-containing ointment, were seen in 20 out of these 35 patients (57%), and sensitization occ...Continue Reading

References

Aug 1, 1975·Contact Dermatitis·J M Lachapelle, D Tennstedt
Aug 1, 1975·Contact Dermatitis·J M Lachapelle
May 1, 1979·Contact Dermatitis·C L Meneghini, G Angelini
Apr 1, 1989·Contact Dermatitis·C M Perret, R Happle
May 1, 1987·Contact Dermatitis·M MelinoP Manuzzi
Jan 1, 1973·Dermatologica·G Smeenk
Oct 1, 1973·Archives Belges De Dermatologie·E Van Hecke
Sep 1, 1983·Contact Dermatitis·K Watanabe, K Yoshikawa
Oct 1, 1993·Contact Dermatitis·M CorazzaA Virgili
Jan 1, 1996·Contact Dermatitis·B KränkeW Aberer

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Citations

Nov 13, 2004·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E WeisshaarS Ständer
Dec 19, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K WaltermannB Kreft
Feb 25, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Brasch
Mar 11, 1999·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·J TadaJ Arata
Feb 27, 1999·Contact Dermatitis·B GniazdowskaB Przybilla
Oct 9, 1999·Contact Dermatitis·S M Cooper, S Shaw
Sep 1, 2005·Contact Dermatitis·D P BruynzeelUNKNOWN European Environmental and Contact Dermatitis Research Group
Oct 4, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jochen BraschAxel Schnuch
Aug 14, 2012·The Australasian Journal of Dermatology·Yan Pan, Rosemary Nixon
Jan 9, 2003·The Veterinary Clinics of North America. Equine Practice·Erin D Malone
Apr 30, 2016·Scientific Reports·Qiang XiaoWeiqiang Lu
Oct 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Birger Kränke, Christian Schuster
Apr 2, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S M Erdmann, H-F Merk

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