Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics

PLoS Pathogens
Albin FontaineLouis Lambrechts

Abstract

The kinetics of arthropod-borne virus (arbovirus) transmission by their vectors have long been recognized as a powerful determinant of arbovirus epidemiology. The time interval between virus acquisition and transmission by the vector, termed extrinsic incubation period (EIP), combines with vector mortality rate and vector competence to determine the proportion of infected vectors that eventually become infectious. However, the dynamic nature of this process, and the amount of natural variation in transmission kinetics among arbovirus strains, are poorly documented empirically and are rarely considered in epidemiological models. Here, we combine newly generated empirical measurements in vivo and outbreak simulations in silico to assess the epidemiological significance of genetic variation in dengue virus (DENV) transmission kinetics by Aedes aegypti mosquitoes. We found significant variation in the dynamics of systemic mosquito infection, a proxy for EIP, among eight field-derived DENV isolates representing the worldwide diversity of recently circulating type 1 strains. Using a stochastic agent-based model to compute time-dependent individual transmission probabilities, we predict that the observed variation in systemic mosquito...Continue Reading

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Citations

Jul 2, 2019·Emerging Microbes & Infections·Jorian PrudhommeAurélien Mercier
Sep 29, 2020·Methods in Ecology and Evolution·Sebastian LequimeGuy Baele
Dec 4, 2019·PLoS Pathogens·Mario NoveloElizabeth A McGraw
Nov 22, 2020·Journal of Medical Virology·Avian V WhiteStephanie L Richards
Nov 6, 2020·Journal of Virology·Fernando MerwaissMaría-Carla Saleh
Apr 1, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Aline Diniz CabralMárcia Aparecida Sperança
Jul 3, 2021·Viruses·Heidi AuerswaldSebastien Boyer

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Datasets Mentioned

BETA
HG316481
MG877552
MG877553
MG877554
MG877555
MG877556
MG877557

Methods Mentioned

BETA
dissection
PCR

Software Mentioned

foreach
Pvclust
ggtree R package
bedtools
phylosignal R package
R Markdown
ArboEpiSim
reshape2
Rstudio
doParallel

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