PMID: 16612479Apr 14, 2006Paper

Epidemiological studies in the information and genomics era: experience of the Clinical Genome of Cancer Project in São Paulo, Brazil

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
V Wünsch-FilhoM A Zago

Abstract

Genomics is expanding the horizons of epidemiology, providing a new dimension for classical epidemiological studies and inspiring the development of large-scale multicenter studies with the statistical power necessary for the assessment of gene-gene and gene-environment interactions in cancer etiology and prognosis. This paper describes the methodology of the Clinical Genome of Cancer Project in São Paulo, Brazil (CGCP), which includes patients with nine types of tumors and controls. Three major epidemiological designs were used to reach specific objectives: cross-sectional studies to examine gene expression, case-control studies to evaluate etiological factors, and follow-up studies to analyze genetic profiles in prognosis. The clinical groups included patients' data in the electronic database through the Internet. Two approaches were used for data quality control: continuous data evaluation and data entry consistency. A total of 1749 cases and 1509 controls were entered into the CGCP database from the first trimester of 2002 to the end of 2004. Continuous evaluation showed that, for all tumors taken together, only 0.5% of the general form fields still included potential inconsistencies by the end of 2004. Regarding data entry...Continue Reading

References

Jun 7, 2002·The Pharmacogenomics Journal·A F WrightH Campbell
Apr 12, 2003·Science·Francis S CollinsAristides Patrinos
Aug 21, 2004·International Journal of Epidemiology·Muin J KhouryMarta Gwinn
Jul 6, 2005·Revista de saúde pública·Victor Wünsch Filho, Marco A Zago

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Citations

May 9, 2012·Journal of Community Genetics·Dafne Dain Gandelman HorovitzAntonia Paula Marques-de-Faria
Sep 22, 2010·Journal of Applied Oral Science : Revista FOB·Maria Gabriela Haye BiazevicVictor Wünsch-Filho
Oct 27, 2018·Revista da Associação Médica Brasileira·Marcus Fernando Kodama Pertille RamosJosé Eluf-Neto

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