Epidemiological study of variations in beta-lactam antibiotic susceptibility of Pseudomonas aeruginosa in two intensive care units

The Journal of Hospital Infection
V CailleauxD Talon

Abstract

A six-month prospective study was carried out in the medical and surgical intensive care units (ICUs) at Besançon University Hospital to assess the frequency and risk factors for beta-lactam-resistant isolates of Pseudomonas aeruginosa. Clinical samples were screened for P. aeruginosa, and four antibiograms were distinguished using imipenem and ceftazidime, namely: fully susceptible (SS), imipenem-resistant (RS), ceftazidime-resistant (SR), and resistant to both (RR). DraI restriction fragment length polymorphism of isolates from different patients or with different resistance patterns but the same serotype was assessed by pulsed-field gel electrophoresis. One hundred and twenty-one isolates were obtained from 50 of 281 patients, 60.3% were fully susceptible. 19.8% imipenem-resistant, 13.2% ceftazidime-resistant, and 6.6% resistant to both. Antibiotic-resistance was independent of serotype. Twenty-two of 32 imipenem-resistant isolates from six patients were of the same DNA type, and six other isolates from four patients were of a second DNA type. On only one occasion did a clonally defined strain develop imipenem resistance. By contrast ceftazidime-resistant strains had differing DNA types, but had been originally ceftazidime-s...Continue Reading

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Citations

Jun 8, 2001·Archives of Medical Research·A L Corona-NakamuraS Aguilar-Benavides
Nov 15, 2002·International Journal of Antimicrobial Agents·M Müller-Premru, T Lejko-Zupanc
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Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elisabeth ParamythiotouAntoine Andremont
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Simone Aranha NouérBeatriz Meurer Moreira
Aug 31, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Carlos Magno C B FortalezaMarcelo de Carvalho Ramos
Apr 5, 2013·Clinical Microbiology Reviews·Vered SchechnerMitchell J Schwaber
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Dec 1, 2001·Scandinavian Journal of Infectious Diseases·G MirandaF Solorzano

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