Epidemiological Trends of Antibiotic Resistant Gonorrhoea in the United Kingdom.

Antibiotics
Lilith K WhittlesXavier Didelot

Abstract

Gonorrhoea is one of the most common sexually-transmitted bacterial infections, globally and in the United Kingdom. The levels of antibiotic resistance in gonorrhoea reported in recent years represent a critical public health issue. From penicillins to cefixime, the gonococcus has become resistant to all antibiotics that have been previously used against it, in each case only a matter of years after introduction as a first-line therapy. After each instance of resistance emergence, the treatment recommendations have required revision, to the point that only a few antibiotics can reliably be prescribed to treat infected individuals. Most countries, including the UK, now recommend that gonorrhoea be treated with a dual therapy combining ceftriaxone and azithromycin. While this treatment is still currently effective for the vast majority of cases, there are concerning signs that this will not always remain the case, and there is no readily apparent alternative. Here, we review the use of antibiotics and epidemiological trends of antibiotic resistance in gonorrhoea from surveillance data over the past 15 years in the UK and describe how surveillance could be improved.

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Citations

Mar 9, 2019·PLoS Computational Biology·Lilith K WhittlesXavier Didelot
Aug 7, 2019·Antimicrobial Agents and Chemotherapy·Deborah A WilliamsonEric P F Chow
Jun 22, 2019·BMC Medicine·Koen B PouwelsJulie V Robotham
Jan 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lilith K WhittlesXavier Didelot
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Apr 25, 2021·The Journal of Antimicrobial Chemotherapy·Selina PatelLaura Shallcross
Apr 2, 2020·Journal of Medicinal Chemistry·Mohamed A SeleemMartin Conda-Sheridan

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