Epidemiology and Antimicrobial Susceptibility of Gram-Negative Pathogens Causing Intra-abdominal Infections in Pediatric Patients in Europe-SMART 2011-2014

Journal of the Pediatric Infectious Diseases Society
Sibylle H LobDaniel F Sahm

Abstract

The most common type of intra-abdominal infection (IAI) is appendicitis, which occurs most frequently in children and young adults. Yet, few studies on the microbiology of pediatric IAI are available, which is problematic because antimicrobial therapy for IAI usually needs to be initiated before microbiological culture results are available. With this study, we aimed to assess whether resistance patterns in pediatric IAI in Europe that would help clinicians select empiric therapy can be identified. Gram-negative pathogens (n = 1259) were collected from pediatric patients as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) in 16 European countries from 2011 to 2014. Minimal inhibitory concentrations (MICs) and extended-spectrum β-lactamase (ESBL) phenotype were determined by broth microdilution according to Clinical and Laboratory Standards Institute guidelines, and susceptibility was interpreted according to European Committee on Antimicrobial Susceptibility Testing guidelines. An IAI was defined as hospital- or community-associated if cultured ≥48 or <48 hours after admission, respectively. Overall, only imipenem and amikacin exceeded 90% susceptibility when all Gram-negative pathogens were combined, an...Continue Reading

References

Feb 1, 1988·Archives of Surgery·D L MollittJ L Talbert
Nov 19, 2009·Pediatric Surgery International·Kin Wai Edwin ChanYuk Him Tam
Jul 29, 2010·The Pediatric Infectious Disease Journal·Romain DumontKarim Asehnoune
Oct 19, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S HawserP Hawkey
Mar 15, 2011·Diagnostic Microbiology and Infectious Disease·Christelle Guillet-CarubaAgnès Ferroni
Jul 19, 2011·Critical Care Research and Practice·Rishi H-P Dhillon, John Clark
Nov 21, 2012·Journal of Pediatric Surgery·Françoise SchmittFrançois Becmeur
Nov 30, 2012·World Journal of Emergency Surgery : WJES·Massimo SartelliJelena Petrovic
Apr 2, 2013·Surgical Infections·Sibylle H LobDaryl J Hoban
Dec 19, 2013·Irish Journal of Medical Science·O ObinwaJ Flynn
Jun 22, 2014·Journal of the American College of Surgeons·Peter C MinneciKatherine J Deans
Nov 9, 2015·Journal of Pediatric Surgery·Joseph HartwichThomas F Tracy

❮ Previous
Next ❯

Citations

Jul 16, 2017·International Journal of Colorectal Disease·Alexander ReinischJuliane Liese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Stephen HawserP Hawkey
© 2022 Meta ULC. All rights reserved