Epidemiology and clinical characteristics of invasive mould infections: A multicenter, retrospective analysis in five Asian countries

Medical Mycology
P RotjanapanB H Tan

Abstract

Formal, large-scale, multicenter studies of invasive mould infection (IMI) in Asia are rare. This 1-year, retrospective study was designed to assess the incidence and clinical determinants of IMI in centers in five countries (Thailand, Taiwan, Singapore, China, India). Patients treated in a single year (2012) were identified through discharge diagnoses, microbiology, and histopathology logs, and entered based on published definitions of IMI. A total of 155 cases were included (median age 54 years; 47.7% male). Of these, 47.7% had proven disease; the remainder had probable IMI. The most frequent host factors were prolonged steroid use (39.4%) and recent neutropenia (38.7%). Common underlying conditions included diabetes mellitus (DM; 30.9%), acute myeloid leukemia (19.4%), and rheumatologic conditions (11.6%). DM was more common in patients with no recent history of neutropenia or prolonged steroid use (P = .006). The lung was the most frequently involved site (78.7%), demonstrating a range of features on computed tomography (CT). Aspergillus was the most common mould cultured (71.6%), primarily A. fumigatus and A. flavus, although proportions varied in different centers. The most often used antifungal for empiric therapy was co...Continue Reading

References

Nov 21, 1997·Archives of Otolaryngology--head & Neck Surgery·R D deShazoR Swain
Dec 23, 1998·Mycoses·N K PandaS B Mann
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Sep 15, 2004·Journal of Clinical Microbiology·Ricardo Araujo, Acacio Gonçalves Rodrigues
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Jun 30, 2006·Medical Mycology·Jiun-Ling WangYee-Chen Chen
May 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Livio PaganoAnnamaria Nosari
Oct 2, 2007·The European Respiratory Journal·P BulpaY Sibille
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Jul 30, 2008·Medical Mycology·Arunaloke ChakrabartiNaresh K Panda
Sep 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yasmine NivoixRaoul Herbrecht
Nov 7, 2009·Postgraduate Medical Journal·A ChakrabartiV Sakhuja
Feb 12, 2010·Journal of Clinical Microbiology·P Lewis WhiteUNKNOWN European Aspergillus PCR Initiative
Mar 6, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Y ParkS-O Lee
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasTom M Chiller
Nov 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio NucciElias Anaissie
Feb 22, 2011·The Science of the Total Environment·Nai-Yun HsuHuey-Jen Su
Sep 13, 2011·Medical Mycology·Monica A Slavin, Arunaloke Chakrabarti
Oct 12, 2011·Immunological Investigations·David A Stevens, George L Melikian
Oct 15, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H-C HsiueP-R Hsueh
Oct 18, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C GirmeniaV Guerrisi
Apr 21, 2012·American Journal of Respiratory and Critical Care Medicine·Stijn I BlotUNKNOWN AspICU Study Investigators
Dec 13, 2012·Annals of the New York Academy of Sciences·Raoul HerbrechtValérie Letscher-Bru
Mar 10, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Y HsuT Y Tan

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Citations

Jan 27, 2018·Journal of Fungi·Intan M W DewiMark S Gresnigt
Mar 1, 2019·Medical Mycology·François DanionOlivier Lortholary
Jul 31, 2018·QJM : Monthly Journal of the Association of Physicians·R SandalP Malhotra
Aug 30, 2020·Infectious Diseases and Therapy·Tananun TanpaibulePorpon Rotjanapan
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Sarah Sze Wah WongVishukumar Aimanianda
Aug 18, 2020·The Journal of Infection·Jon Salmanton-GarcíaUNKNOWN ECMM/ISHAM working group

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