Epidemiology and clinical outcomes of hepatitis delta (D) virus infection in Queensland, Australia

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Sarah CoghillKrispin Hajkowicz

Abstract

To investigate the epidemiology, clinical characteristics and outcomes of those with hepatitis delta virus (HDV) infection in Queensland, Australia. Retrospective cohort study of individuals tested for HDV between 1997 and 2016 in the public healthcare system in Queensland. 179 individuals recorded positive HDV serology between 1997 and 2016, with a total of 4407 individuals undergoing testing (seroprevalence 4.1%). The majority of HDV positive individuals were male and were born overseas. Those born in Africa had a higher risk ratio (RR) for HDV infection (RR, 1.55; 95% CI, 1.14-2.09); being born in Asia was associated with a relatively lower risk of HDV infection (RR, 0.36; 95% CI, 0.27-0.58). Positive hepatitis C virus (HCV) serology was significantly associated with positive HDV serology (RR, 2.98; 95% CI, 2.36-3.78). Of the HDV positive individuals born in Australia, the majority were HCV positive (69.8%). HDV positive individuals were less likely to be Hepatitis B e antigen (HBeAg) positive (RR, 0.64; 95% CI, 0.45-0.93) and recorded lower hepatitis B virus (HBV) viral loads. Positive HDV serology was associated with increased risk of liver cirrhosis (RR, 2.3; 95% CI 1.73-3.07) and liver transplantation (RR, 1.93; CI 1.31-...Continue Reading

Citations

Nov 14, 2019·Alimentary Pharmacology & Therapeutics·Adriana PalomMaria Buti
Dec 17, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtObaid S Shaikh
Mar 8, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Habiba KamalSoo Aleman
Jun 2, 2020·Gastroenterology Report·Ben L DaChristopher Koh
Jan 24, 2021·Journal of Hepatology·Mario RizzettoFranco Negro
Apr 4, 2021·Viruses·Mario Rizzetto, Tommaso Stroffolini
Oct 7, 2021·Journal of Gastrointestinal Cancer·A BaskiranS Akbulut

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