Epidemiology and health outcomes of sarcoidosis in a universal health care population: a cohort study

The European Respiratory Journal
Lee M FidlerAndrea Gershon

Abstract

Sarcoidosis related mortality appears to be rising in North America, with increasing rates in women and the elderly. We aimed to estimate trends in sarcoidosis incidence, prevalence and mortality in Ontario, Canada.We performed a cohort study using health administrative data from Ontario between 1996 and 2015. International Classification of Diseases and Ontario Health Insurance Plan codes were used for case detection. Three disease definitions were created; (1) sarcoidosis, >/=2 physician claims within 2 years; (2) chronic sarcoidosis, >/=5 physician claims within 3 years; (3) sarcoidosis with histology, >/=2 physician claims with a tissue biopsy performed between claims.Overall, 18 550, 9199, and 3819 individuals with sarcoidosis, chronic sarcoidosis and sarcoidosis with histology were identified. The prevalence of sarcoidosis was 143 per 100 000 in 2015, increasing by 116% (p<0.0001) from 1996. The increase in age-adjusted prevalence was higher in men than women (136% versus 99%, p<0.0001). The incidence of sarcoidosis declined from 7.9 to 6.8 per 100 000 between 1996 and 2014 (15% decrease, p=0.0009). A 30.3% decrease in incidence was seen amongst females (p<0.0001), compared to a 5.5% increase in men (p=0.47). Age- and sex...Continue Reading

References

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Oct 27, 2018·Therapeutic Advances in Chronic Disease·Elizabeth V Arkema, Yvette C Cozier

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Citations

Jul 24, 2020·Current Opinion in Pulmonary Medicine·Elizabeth V Arkema, Yvette C Cozier
Apr 10, 2021·Annals of the American Thoracic Society·Lee M FidlerMeyer Balter
May 30, 2021·European Journal of Internal Medicine·Raúl Fernández-RamónRicardo Blanco

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