Epidemiology and in vitro activity of antimycotics against candidal vaginal/skin/nail infections in Singapore

International Journal of Dermatology
Y K KwokC S Seow

Abstract

Candidal infections of the skin/nails and vagina are very common worldwide. Various in vitro test systems are available to help to determine the antifungal activity of drugs. The minimum inhibitory concentration (MIC) is a standard measure of the in vitro potency of drugs against yeasts. Vaginal smears and skin/nail scrapings of 50 consecutive patients with candidal vaginitis and 46 consecutive patients (28 women, 18 men) with cutaneous/nail candidosis were used in the study. Direct microscopy and culture from vaginal smears and skin scrapings were performed on all patients. The MICs were determined using the broth dilution method. For vaginal candidosis, the mean age of the patients was 28.2 years (range, 9-49 years). Candida albicans accounted for 58% of the isolates, C. glabrata for 32%, C. tropicalis for 6%, and C. parasilosis for 4%. At the MIC of < or = 4 mg/L, 65-95% of C. albicans, 66-94% of C. glabrata, 33-100% of C. tropicalis, and 0-50% of C. parasilosis were susceptible to the drugs tested (ketoconazole, itraconazole, nystatin, amorolfine, clotrimazole, and miconazole). For cutaneous/nail candidosis, the mean age of the patients was 45 years (range, 19-82 years). C. albicans made up 59% of the isolates, C. parasilos...Continue Reading

Citations

Feb 8, 2002·Folia Microbiologica·J JautováE Holoda
Mar 13, 2003·Folia Microbiologica·E DorkoA Wantrubová
May 12, 2012·Mycoses·F Fernández-CamposA C Calpena Campmany
May 24, 2014·Revista iberoamericana de micología·Lívia de Souza RamosDiana Bridon da Graça Sgarbi
Oct 5, 2010·Critical Reviews in Microbiology·Louis Yi Ann ChaiPeter Warn
Jun 2, 2009·Mycopathologia·J A M S JayatilakeG J Panagoda
Dec 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Lin TsaiYa-Ying Wang

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