Epidemiology and Mechanisms of Uremia-Related Cardiovascular Disease

Circulation
Marcello TonelliRavi Thadhani

Abstract

Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors that arise from accumulating toxins also contribute to the pathogenesis of CVD. In this review, we summarize the literature on the epidemiology of both traditional and uremia-related CVD and focus on postulated mechanisms of the latter. In the context of current and emerging diagnostics and therapies for CVD, we highlight what we interpret as major gaps in the medical management of this growing population that need to be addressed with targeted epidemiological and translational research. Finally, we describe the global challenges associated with the recognition and management of uremia-related CVD in developed and developing nations.

References

Mar 16, 1989·The New England Journal of Medicine·S Klahr
Jul 1, 1995·Kidney International·Z A MassyB L Kasiske
Jun 1, 1996·American Heart Journal·S AbeG Sloman
May 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K TakedaM Fujishima
Sep 17, 1998·The New England Journal of Medicine·C A HerzogA J Collins
Oct 18, 2000·Annals of Internal Medicine·S J Pinto-SietsmaP E de Jong
Feb 15, 2001·Archives of Internal Medicine·A E Smith Sehdev, G M Hutchins
Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A G Stack, W E Bloembergen
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Jan T KielsteinDanilo Fliser
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Christopher S Wilcox
Mar 30, 2002·Journal of the American College of Cardiology·Patricia J M BestPeter B Berger
May 25, 2002·Kidney International·Christopher T ChanAndreas Pierratos
Aug 8, 2002·Kidney International·Masahiko TozawaShuichi Takishita
Aug 17, 2002·The Journal of Pediatrics·R S ParekhF K Port
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Esther M BrigantiRobert C Atkins
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Oct 24, 2002·The New England Journal of Medicine·Biff F Palmer
Dec 14, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paul E de JongDick de Zeeuw
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Apr 16, 2003·Kidney International. Supplement·Karin Tyralla, Kerstin Amann
May 14, 2003·Journal of the American College of Cardiology·Gennaro CiceRaffaele Calabrò
Jul 9, 2003·Kidney International·Stephen L SeligerCatherine O Stehman-Breen
Aug 2, 2003·The New England Journal of Medicine·Ming TengRavi Thadhani
Aug 26, 2004·Kidney International·Luana PillonGlenn M Chertow
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Glenn M ChertowBarbara J McNeil
Sep 29, 2004·Circulation·Brenda R HemmelgarnUNKNOWN Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) Investigators
Oct 16, 2004·Kidney International. Supplement·Jacobien C VerhaveUNKNOWN PREVEND Study Group
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Ming TengRavi Thadhani
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Donal N ReddanWilliam F Owen
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kazunori ToyodaMitsuo Iida
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators

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Citations

Sep 11, 2016·Journal of Electrocardiology·Dimitrios Poulikakos, Marek Malik
Aug 11, 2016·Clinical Journal of the American Society of Nephrology : CJASN·James S FloydDelia Scholes
Feb 27, 2017·American Journal of Nephrology·Ivano BaragettiPaolo Fiorina
Mar 7, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ju-Yeh YangKuan-Yu Hung
Jan 16, 2018·Oxidative Medicine and Cellular Longevity·Anila DuniEvangelia Dounousi
Feb 13, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lucia Del VecchioFrancesco Locatelli
Feb 20, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karim BelmokhtarFatouma Touré
Mar 5, 2019·Clinical and Experimental Nephrology·Hideki FujiiShinichi Nishi
Jun 11, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Charmaine E Lok
Mar 14, 2019·American Journal of Physiology. Renal Physiology·Gerren P HobbyJohn M Arthur
Jun 21, 2019·Journal of Atherosclerosis and Thrombosis·Toshiaki Nakano
Nov 9, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Toshiaki NakanoTakanari Kitazono
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ye YangChangsheng Zhao
Mar 13, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernard CanaudFrank Maddux
Feb 20, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sunita PaudyalLaura Carbone
Apr 14, 2020·Clinical and Experimental Nephrology·Yukimasa IwataYoshitaka Isaka
May 1, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juan C KupfermanSteven G Pavlakis
Sep 1, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cédric VillainZiad A Massy
Dec 29, 2018·Circulation·Friedrich F Hoyer, Matthias Nahrendorf
Dec 16, 2016·European Heart Journal·Fernando Alfonso, Fernando Rivero
Mar 28, 2020·Mediators of Inflammation·Yueqiang WenXianfeng Wu
Feb 26, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juan C KupfermanStephen R Hooper
Aug 12, 2017·Hemodialysis International·Bahman Jabbari, Nosratola D Vaziri
Sep 27, 2020·The European Journal of Neuroscience·Birva ShahPallab Bhattacharya
Jul 28, 2020·Cardiovascular Research·Eva Roy-ChowdhurySibylle von Vietinghoff

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