Epidemiology and phylogenetic analysis of hepatitis D virus infection in Australia

Internal Medicine Journal
Kathy JacksonMargaret Littlejohn

Abstract

The incidence and trends of the hepatitis D virus (HDV) in Australia have not been recently assessed, and the circulating genotypes have never been determined. To characterise the current virology and epidemiology of HDV. Notifiable disease surveillance and laboratory testing data were analysed to assess demographics, risk factors and trends. HDV serology and RNA testing were performed on requested samples from 2010 to 2016. Sequencing of a 500-nucleotide amplicon of the delta antigen and phylogenetic analysis of the strains from 2009 to 2016 were also conducted. Ninety HDV notifications were reported to the Victorian Department of Health and Human Services between 2010 and 2016. The majority (64.4%) of those diagnosed were born overseas, most commonly in Sudan, Pakistan and Vietnam. Over the same period, 190 patients tested positive for anti-HDV serology and 166 for HDV RNA. Sequencing of isolates from 169 individuals between 2009 and 2016 found that 80.5% strains were genotype 1, 16% genotype 5 and 3.5% genotype 2. Phylogenetic analysis confirmed the relatedness of strains from birth country, demonstrated the presence of the 'Pacific Island' genotype 1 strain in Queensland and supported possible transmission in correctional f...Continue Reading

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Citations

Apr 13, 2019·Journal of Medical Virology·Kathy JacksonStephen Locarnini
Jul 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sofia ParaskevopoulouChristian Drosten

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