Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: a 12-year review

Journal of the European Academy of Dermatology and Venereology : JEADV
H L J LimS H Tan

Abstract

Limited information exists regarding survival of Asian patients with mycosis fungoides (MF) and Sézary syndrome (SS). To evaluate the epidemiology, outcome and prognostic factors of these patients. A retrospective review of MF/SS cases diagnosed from 2000 to 2011 at a tertiary referral dermatology centre in Singapore was performed. Of 246 patients, 63% were male and the median age at diagnosis was 49 years. 73.2% were Chinese, 12.6% Indian, 6.9% Malay and 7.3% Caucasian. A total of 239 patients (97.2%) had MF and seven had SS. Median follow-up duration was 6.3 years, and median duration of symptoms at diagnosis was 13 months. For patients with MF, the majority had early disease (92.8% stage IA-IIA). 3.8% were stage IIB, 1.7% stage III and 1.7% stage IV. Complete response to treatment occurred in 78.2%, partial response in 9.6%, persistent but non-progressive disease in 10.0% and disease progression in 4.1% of patients. Large cell transformation occurred in 4.1% of patients. Mean overall survival during this study was 12.7 years, with death occurring in 2.5% of patients (all ≥stage IIB at diagnosis). For patients with SS, 71.4% presented with stage IVA disease, 28.6% stage IVB. Complete response to treatment occurred in 14.2%, p...Continue Reading

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Citations

Jul 2, 2019·The British Journal of Dermatology·H-Z ShiH Chen
Nov 30, 2019·International Journal of Dermatology·Polytimi SidiropoulouAlexander Stratigos
Oct 19, 2020·The Australasian Journal of Dermatology·Hui Mei ChengWee Ping Tan
Jan 20, 2021·Journal of the American Academy of Dermatology·Sara BehbahaniSteven T Chen
Apr 20, 2021·Indian Journal of Dermatology, Venereology and Leprology·Ploysyne RattanakaemakornNatta Rajatanavin
May 16, 2021·International Journal of Dermatology·Ik Jun MoonMi Woo Lee
Jul 9, 2021·BioMed Research International·Chutipon PruksaeakananManasmon Chairatchaneeboon
Aug 27, 2021·International Journal of Dermatology·Denis Miyashiro, José A Sanches

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