Epidemiology and risk factors for invasive fungal disease in liver transplant recipients in a tertiary transplant center.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Lionel LumRebecca Davis

Abstract

Invasive fungal disease (IFD) in liver transplant recipients causes significant morbidity and mortality. We aim to describe institutional epidemiology and risk factors for IFD in the liver transplant population. We conducted a retrospective cohort study of all adult liver transplant recipients in our institution from 2005 to October 2015 to describe the epidemiology of patients with proven and probable IFD according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. To determine risk factors for IFD, a case-control study was also conducted. Cases were defined as liver transplant recipients with proven or probable IFD, and controls were defined as liver transplant recipients without IFD. Each case was matched to two controls by age (±10 years of age), gender, and time of transplant (within one year of the case). 28/554 (5.1%) patients developed IFD. Candidiasis (n = 11; 39.3%), Aspergillosis (n = 10; 35.7%), and Cryptococcosis (n = 3; 10.7%) were the most common fungal infections in the proven and probable IFD groups. Mold infections occurred in 13 (46.4%) cases. Reoperation, roux-en-y anastomosis, and massive intraoperative transfusion of ≥40 units of cellular blood products were maj...Continue Reading

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Citations

Jun 3, 2021·Current Fungal Infection Reports·Garret T Seiler, Luis Ostrosky-Zeichner
Jun 25, 2021·World Journal of Transplantation·Ramesh KumarRajeev Nayan Priyadarshi
Oct 19, 2021·Antimicrobial Agents and Chemotherapy·Claire PressiatEric Levesque

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