Epidemiology and risk factors: intrahepatic cholangiocarcinoma

Hepatobiliary Surgery and Nutrition
Amar Gupta, Elijah Dixon

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a rare entity with a distinct clinical course and epidemiology from hilar and extrahepatic cholangiocarcinoma. ICC makes up 8-10% of cholangiocarcinomas and 10-20% of all primary liver tumors. There remains a considerable amount of geographic variation in the incidence of ICC worldwide; however, the overall incidence of this malignancy appears to be rising. Several risk factors have been identified, such as infectious causes (liver flukes, viral hepatitis), biliary tract disease [primary sclerosing cholangitis (PSC), hepaticolithiasis, biliary cystic diseases], metabolic syndrome, lifestyle choices (alcohol abuse, tobacco use), and cirrhosis. Despite this, a substantial number of ICC patients do not have any identifiable risk factors, underlining the need for further work into the pathogenesis of this malignancy.

Citations

Apr 13, 2018·Genome Research·Stephanie N SchauerGeoffrey J Faulkner
Sep 23, 2020·Journal of Gastrointestinal Cancer·Anand BardiaPuneet Pareek
Mar 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrea RuzzenenteAlfredo Guglielmi
Jan 10, 2020·Journal of Clinical and Translational Hepatology·Antonio GiorgioValentina Giorgio
Aug 26, 2018·Cancers·Jomnarong LertsuwanJutamaad Satayavivad
May 31, 2018·Journal of Experimental & Clinical Cancer Research : CR·Feng XuChaoliu Dai
Mar 2, 2019·BMC Cancer·Peter L LabibStephen P Pereira
Sep 22, 2020·World Journal of Gastroenterology : WJG·Michela Anna PolidoroMatteo Donadon
Jan 23, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun Jiang, Barbara A Centeno
Jan 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Longfei DaiShusen Zheng
Apr 27, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Rui ChengYanling Chen
Jul 1, 2020·Clinical Pathology·Bita Geramizadeh
Oct 13, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicolás GoldaracenaGonzalo Sapisochin
Oct 1, 2020·International Journal of Cancer. Journal International Du Cancer·Xizi Shen, Xingping Shen
Feb 23, 2021·European Journal of Pharmacology·Tawit SuriyoJutamaad Satayavivad
May 4, 2021·Digestive Diseases and Sciences·Fatma El Zahraa MohamedRajai Munir Al-Jehani
Jun 3, 2021·Journal of Clinical Medicine·Guergana PanayotovaKeri E Lunsford
Jun 3, 2021·Cancers·Yuichiro HatanoAkira Hara
Aug 31, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Fabian BartschHauke Lang
May 24, 2019·International Journal of Surgery·Fabian BartschHauke Lang
Jul 24, 2021·Pathologica·Samantha SarcognatoMaria Guido

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