Abstract
Systemic sclerosis (SSc) may overlap with systemic lupus erythematous (SLE). Little is known about the epidemiology, clinical characteristics, and survival of SSc-SLE overlap. We evaluated the prevalence of SSc-SLE overlap and differences in SSc characteristics, and compared survival with SSc without SLE. A cohort study was conducted including subjects who fulfilled the American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for SSc and/or the ACR criteria for SLE. The primary outcome was time from diagnosis to all-cause mortality. Survival was evaluated using Kaplan-Meier and Cox proportional hazard models. We identified 1252 subjects (SSc: n = 1166, SSc-SLE: n = 86) with an SSc-SLE prevalence of 6.8%. Those with SSc-SLE were younger at diagnosis (37.9 yrs vs 47.9 yrs, p < 0.001), more frequently East Asian (5.5% vs 20%) or South Asian (5.1% vs 12%), had lupus anticoagulant (6% vs 0.3%, p < 0.001), anticardiolipin antibody (6% vs 0.9%, p < 0.001), and pulmonary arterial hypertension (PAH; 52% vs 31%, p < 0.001). Those with SSc-SLE less frequently had calcinosis (13% vs 27%, p = 0.007), telangiectasia (49% vs 75%, p < 0.001), and diffuse subtype (12% vs 35%, p < 0.001). There were no si...Continue Reading
References
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1995·Autoimmunity·U PicilloG Tirri
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology·T Sasaki, H Nakajima
Sep 1, 1995·Cancer·A K RosenthalO Nyrén
Oct 27, 1997·Arthritis and Rheumatism·M C Hochberg
Jan 5, 2002·Arthritis and Rheumatism·A L WutzlA L Herrick
Nov 1, 2002·Current Opinion in Rheumatology·Janet E Pope
Jan 22, 2005·Clinical Rheumatology·Javier Alberto CavallascaGustavo Guillermo Nasswetter
Oct 19, 2006·Rheumatology International·Paola CaramaschiLisa Maria Bambara
Sep 26, 2007·Annals of the New York Academy of Sciences·Gisele Zandman-GoddardPnina Langevitz
Oct 2, 2007·Arthritis and Rheumatism·Sindhu R JohnsonDaniel H Solomon
Jun 3, 2008·Rheumatology·N HunzelmannUNKNOWN Registry of the German Network for Systemic Scleroderma
Aug 17, 2011·The Journal of Rheumatology·Angela PakozdiChristopher P Denton
Jan 17, 2012·The Journal of Rheumatology·Sindhu R JohnsonBrian M Feldman
Jun 25, 2013·Autoimmunity Reviews·Muriel ElhaiYannick Allanore
Oct 5, 2013·Annals of the Rheumatic Diseases·Frank van den HoogenJanet E Pope
Jan 7, 2014·Annals of the Rheumatic Diseases·Pia MoinzadehUNKNOWN all participating DNSS centers
Jun 3, 2014·Arthritis Research & Therapy·Kavish J BhansingMadelon C Vonk
Oct 3, 2014·The Journal of Rheumatology·Haseena HusseinSindhu R Johnson
Nov 8, 2014·Lung India : Official Organ of Indian Chest Society·Vivek S GuleriaShankar Subramanian
Apr 16, 2015·Current Rheumatology Reports·Sindhu R Johnson
Jul 28, 2015·Autoimmunity Reviews·Cristiana AlmeidaCarlos Vasconcelos
Apr 30, 2016·International Journal of Rheumatic Diseases·Chingching FoocharoenRatanavadee Nanagara
Jul 5, 2016·Journal of Clinical Epidemiology·Medha L SoowamberSindhu R Johnson
May 1, 2016·Journal of Scleroderma and Related Disorders·Sindhu R JohnsonDaniel E Furst
Citations
Nov 18, 2019·Rheumatology and Therapy·Sara L GaleKhaled Sarsour
Nov 11, 2019·Scientific Reports·Nozomi YokoyamaNaoyuki Tsuchiya
Sep 13, 2018·Rheumatology International·Thapat Wannarong, Chayawee Muangchan
Nov 9, 2019·Rheumatology International·Ali TaylanBahar Engin
Sep 12, 2020·IJU Case Reports·Masayuki KurokawaNorihiko Tsuchiya
Dec 31, 2019·Journal of Immunology Research·Dan WangJiexin Zhang
Oct 9, 2020·Medicine·Xiaodong XieHongrui Dong
Jun 1, 2021·International Journal of Rheumatic Diseases·Nasra K Al-AdhoubiHumaid A Al Wahshi
Oct 10, 2021·International Journal of Rheumatic Diseases·Hironari HanaokaTsutomu Takeuchi