Abstract
Invasive candidiasis (IC) is the most common cause of invasive fungal infections. Identification of risk factors for such infection may help in the empirical therapeutic decision-making process. We conducted this study to characterize the clinical epidemiology of such infection and to differentiate risk factors between Candida albicans and Candida non-albicans species. We retrospectively evaluated patients with IC from 2011 to 2013. Clinical data, antibiotic therapy, underlying condition, and invasive procedures were analyzed and compared between C. albicans and C. non-albicans species. C. albicans was the most frequently isolated Candida species (48.6% of all IC patients), although C. non-albicans spp. were more commonly isolated overall. C. albicans, Candida tropicalis, and Candida parapsilosis have a high susceptibility rate to all antifungal agents (>90%), whereas Candida glabrata showed decreased susceptibility to fluconazole and itraconazole. Amphotericin B demonstrated excellent antifungal activity against all Candida species. Univariate analyses showed that IC patients with C. albicans had a higher ratio of older age (p = 0.008), solid tumor (p = 0.029), and hypoproteinemia (p = 0.019), whereas those with C. non-albican...Continue Reading
References
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Abi-SaidS Vartivarian
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ViscoliF Meunier
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M BlumbergUNKNOWN National Epidemiology of Mycoses Survey(NEMIS) Study Group
Jul 27, 2001·Epidemiology and Infection·T L LamagniE M Johnson
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M McNeilD W Warnock
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Olafur GudlaugssonDaniel Diekema
Nov 1, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Sep 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Daniel J Diekema, Michael A Pfaller
Apr 9, 2005·BMC Infectious Diseases·Ming-Fang ChengHsiu-Jung Lo
Sep 21, 2006·Infectious Disease Clinics of North America·Peter G Pappas
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Mar 28, 2009·Critical Care Medicine·Olivier LeroyUNKNOWN AmarCand Study Group
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Feb 19, 2010·Journal of Clinical Microbiology·M A PfallerUNKNOWN Global Antifungal Surveillance Group
Mar 26, 2010·Pharmacotherapy·Heather M ArnoldMarin H Kollef
Aug 28, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Matthew E FalagasKonstantinos Z Vardakas
Dec 15, 2010·Diagnostic Microbiology and Infectious Disease·Michael A PfallerRonald N Jones
Dec 21, 2010·Critical Care Medicine·Daniel H KettUNKNOWN Extended Prevalence of Infection in ICU Study (EPIC II) Group of Investigators
Jan 10, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Almudena Moreno Elola-OlasoRoberto Gedaly
Apr 2, 2013·The Journal of Antimicrobial Chemotherapy·Fengmei GuoUNKNOWN China-SCAN Team
Jan 16, 2014·The Journal of Antibiotics·Katsumi ShigemuraSoichi Arakawa
Jan 30, 2014·PloS One·Daniel PrietoJesus Pla
Citations
Jul 22, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ming-Chi LiWen-Chien Ko
Dec 3, 2015·International Journal of Antimicrobial Agents·A El ZakhemS S Kanj
Aug 6, 2016·The Journal of Antimicrobial Chemotherapy·B LissH Wisplinghoff
Jan 27, 2018·Journal of Fungi·Małgorzata BondarykZofia Urbańczyk-Lipkowska
Apr 6, 2019·Geriatrics & Gerontology International·Wenxue HuWenke Hao
Jan 31, 2018·Frontiers of Medicine·Min ChenWanqing Liao
Nov 11, 2018·Lasers in Medical Science·Suryani D Astuti Suhariningsih
Nov 22, 2019·Frontiers in Microbiology·Xiuyun LiLina Hao
Apr 27, 2018·Frontiers in Microbiology·Fabio ScordinoOrazio Romeo
Jun 5, 2019·Antimicrobial Resistance and Infection Control·Zengli XiaoYouzhong An
Nov 9, 2019·BMC Infectious Diseases·Zhang-Rui ZengJian Deng
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Yaling LiXiuhao Guan
Jul 16, 2019·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ming-Horng TsaiJang-Jih Lu