Epidemiology, detection, and management of tuberculosis among end-stage renal disease patients

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Reiko C OkadaAmit S Chitnis

Abstract

Tuberculosis (TB) remains an important problem among end-stage renal disease (ESRD) patients. We reviewed the epidemiology of TB and ESRD, investigations of TB exposures in US dialysis facilities, and published guidelines to inform screening and treatment practices among US ESRD patients. Compared to TB in the general population, ESRD patients have 6-25-fold higher TB incidence rates, and mortality during treatment is 2-3-fold higher. Most TB cases among ESRD patients (~90%) occur among non-US-born persons, and an analysis of genotyping data suggests that 80% of all cases result from latent TB infection (LTBI) reactivation. Published TB contact investigations in dialysis facilities have reported cases among ESRD patients and healthcare workers. However, transmission of TB is rare: there were no reports of secondary cases of TB because of exposure to an index-case patient and there were few TB infections, which was demonstrated by low occurrence of newly positive tuberculin skin tests (12%-16%) and conversions (8%-17%) among contacts. Targeted TB education, screening, and treatment for ESRD patients at highest risk for TB exposure (eg, non-US-born persons), using interferon-gamma release assays and short course LTBI regimens (ie...Continue Reading

References

Nov 1, 1989·The American Review of Respiratory Disease·H F LecoeurJ H Grosset
Sep 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·T A SimonJ I Tokars
Jun 16, 2001·Nephron·K J ChouH M Chung
Aug 7, 2002·American Journal of Infection Control·Jeanne A LinquistFrank Alvarez
Jan 22, 2003·Seminars in Dialysis·Magdi M HusseinHaysam Roujouleh
Jun 3, 2004·American Journal of Respiratory and Critical Care Medicine·Dick MenziesKevin Schwartzman
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mary M KloteKevin Abbott
Jan 14, 2005·International Journal of Clinical Practice·R ErkocK Uzun
Jan 5, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S VikrantS N Mehta
Feb 14, 2006·American Journal of Respiratory and Critical Care Medicine·Mauro SchechterRichard E Chaisson
Sep 14, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mary M KloteKevin C Abbott
Jun 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Kevin L WinthropGerald H Mazurek
Aug 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sawako KatoBengt Lindholm
Dec 17, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D Lopez de Castilla, N W Schluger
Apr 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Liviu Segall, Adrian Covic
Jul 8, 2011·The New England Journal of Medicine·Neil A MartinsonRichard E Chaisson
Dec 14, 2011·The New England Journal of Medicine·Timothy R SterlingUNKNOWN TB Trials Consortium PREVENT TB Study Team
Jan 5, 2012·PloS One·Claudia C DoblerGuy B Marks
Jun 15, 2012·Seminars in Dialysis·Robert M A Richardson
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas E RogersonAngela C Webster
Apr 23, 2014·American Journal of Nephrology·Amit S ChitnisPennan M Barry
Nov 29, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K Al-EfraijJ Johnston
Aug 2, 2017·ESMO Open·Andrés Cervantes, María José Terol
Aug 2, 2017·Annals of Internal Medicine·Dominik ZennerMarieke J van der Werf
Oct 20, 2017·JAMA Internal Medicine·Jennifer Flood, Pennan M Barry

❮ Previous
Next ❯

Citations

Apr 9, 2020·BMC Surgery·Tewodross Getu WoldeJishu Wei
Aug 28, 2021·Journal of Racial and Ethnic Health Disparities·Yuri P SpringerAdam J Langer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.