Epidemiology in neurobiological research: exemplified by the influenza-schizophrenia theory

The British Journal of Psychiatry. Supplement
P Munk-Jørgensen, H Ewald

Abstract

During recent years the strategy for aetiological research in schizophrenia has been to concentrate on two closely connected directions: the search for the genetic element and the search for environmental factors. Damage to the immature brain during pregnancy and delivery has given us the most interesting results from recent environmental research. To examine the validity of the influenza-schizophrenia hypothesis. A review of register-based epidemiological studies in Denmark conducted over a 10-year period. The studies reviewed provided strong inferential evidence in favour of the hypothesis, but some methodological problems are unresolved and not all replication studies have been positive. The brain-damage hypothesis points to possibilities for identifying high-risk individuals at an early stage of life and perhaps establishing specific preventive programmes. There is, however, a great need for closer international collaboration in future research.

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Citations

Apr 6, 2004·Brain Research. Brain Research Reviews·Patricia Boksa
Feb 15, 2005·BMC Medical Genetics·Daniel R Hanson, Irving I Gottesman
Dec 5, 2006·Medical Hypotheses·Mauro Garcia-Toro, Iratxe Aguirre
Jun 24, 2005·Neuroreport·Linnéa AspHåkan Karlsson
Sep 16, 2005·Journal of Neurovirology·Johan BraskKrister Kristensson
Apr 24, 2001·The British Journal of Psychiatry. Supplement·B Cooper
May 27, 2003·Clinical Chemistry·Håkan KarlssonKrister Kristenssson
Mar 27, 2003·Neuroreport·Håkan Karlsson
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·A T Cheng, B Cooper
May 29, 2004·Trends in Neurosciences·Akira SawaAtsushi Kamiya

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