PMID: 9635236Jun 23, 1998Paper

Epidemiology, laboratory detection, and therapy of penicillin-resistant streptococcal infections

Diagnostic Microbiology and Infectious Disease
R N Jones, W R Wilson

Abstract

Streptococci cause a wide range of infections in humans including respiratory tract infections, endocarditis, meningitis, bacteremias, and skin and soft tissue lesions. Mutations in the penicillin binding proteins target sites in these organisms have recently caused resistance to penicillins and cephalosporins. The passage of resistant genetic material from one streptococcal species to another has been recognized as one of the mechanisms by which this resistance has occurred and spread. Such resistance has been a particular problem in Streptococcus pneumoniae and viridans group streptococci with penicillin resistance levels in excess of 25%, now common in both groups of organisms worldwide. Fourth-generation cephalosporins, with their enhanced antibacterial activity against Gram-positive organisms (cefpirome > cefepime) and their increased stability to the beta-lactamases produced by many bacterial species, offer a new option for the treatment of potentially life-threatening infections such as pneumococcal pneumonia and meningitis with or without bacteremia. Clinical trials are currently in place to evaluate the role of these agents in these, and other, indications of Gram-positive infections. Prior studies of cefpirome therapy...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C G DowsonB G Spratt
Jul 1, 1989·Reviews of Infectious Diseases·C E CherubinG Overturf
Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Martínez-BeltránF Baquero

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Citations

Apr 17, 2001·Antimicrobial Agents and Chemotherapy·S ChamberlandM N Dudley
Jun 28, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Motohiro TakeuchiMitsufumi Mayumi
Oct 22, 2010·The American Journal of Medicine·Catherine Hsu Ling HongPeter B Lockhart
Dec 11, 1999·The Journal of Antimicrobial Chemotherapy·J M EntenzaP Moreillon
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Therese M Chapman, Caroline M Perry
Dec 11, 2003·Dental Clinics of North America·Thomas J Pallasch
Dec 22, 1999·The Joint Commission Journal on Quality Improvement·S S SonnadS J Bernstein

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