Epidemiology of acute febrile illness in Latin America

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
J MoreiraAndré Machado Siqueira

Abstract

The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. To review studies on community-acquired fever aetiology other than malaria in Latin America, and to highlight knowledge gaps and challenges needing further investigation. PubMed from 2012 to April 2018. We found 17 eligible studies describing 13 539 patients. The median number of pathogens tested per individual was 3.5 (range 2-17). A causative pathogen could be determined for 6661 (49.2%) individuals. The most frequently reported pathogen during the study periods was dengue virus (DENV) (14 studies), followed by chikungunya virus (nine studies) and Zika virus (seven studies). Among the studies reporting concurrent infections, 296 individuals (2.2%) were found to have co-infections. In-hospital mortality was reported in eight (47%) studies, ranging between 0% and 18%. DENV fever is the febrile illness most frequently reported, reflecting its importance, while chi...Continue Reading

Citations

Dec 31, 2018·The American Journal of Tropical Medicine and Hygiene·L Gayani TillekeratneChristopher W Woods
Nov 16, 2019·PLoS Neglected Tropical Diseases·Chulwoo RheeKevin R Clarke
Aug 20, 2020·PLoS Neglected Tropical Diseases·Leticia Del Carmen Castillo SignorLuis E Cuevas
Sep 22, 2020·PLoS Neglected Tropical Diseases·Tyler M SharpBrenda Rivera-Garcia
Aug 26, 2018·Nature Microbiology·Marc Lecuit, Laurent Nguyen
Mar 28, 2020·PloS One·Fernando Gongora-RiveraUNKNOWN GBS HU-IMSS Working Group
Sep 6, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacob D BallMadsen Beau de Rochars
Sep 22, 2020·BMC Medicine·José MoreiraAndre M Siqueira
Dec 23, 2020·Emerging Infectious Diseases·Sebastián Muñoz-LealMarcelo B Labruna
Jul 7, 2021·Expert Review of Anti-infective Therapy·Giorgia SulisSumanth Gandra
Aug 23, 2021·BMC Infectious Diseases·Julianne MeisnerPeter M Rabinowitz

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT03047642

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